Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma

Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are limited since they are often ineffective. Local acidosis derived from glycolytic carcinoma and tumor-induced osteolysis is only barely explore...

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Detalles Bibliográficos
Autores principales: Di Pompo, Gemma, Lemma, Silvia, Canti, Lorenzo, Rucci, Nadia, Ponzetti, Marco, Errani, Costantino, Donati, Davide Maria, Russell, Shonagh, Gillies, Robert, Chano, Tokuhiro, Baldini, Nicola, Avnet, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589596/
https://www.ncbi.nlm.nih.gov/pubmed/28903357
http://dx.doi.org/10.18632/oncotarget.17091

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