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Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort

PURPOSE: While many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic,...

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Autores principales: Fassier, Philippine, Zelek, Laurent, Bachmann, Patrick, Touillaud, Marina, Druesne-Pecollo, Nathalie, Partula, Valentin, Hercberg, Serge, Galan, Pilar, Cohen, Patrice, Hoarau, Hélène, Latino-Martel, Paule, Srour, Bernard, Gonzalez, Rebeca, Deschasaux, Mélanie, Touvier, Mathilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589610/
https://www.ncbi.nlm.nih.gov/pubmed/28903371
http://dx.doi.org/10.18632/oncotarget.17676
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author Fassier, Philippine
Zelek, Laurent
Bachmann, Patrick
Touillaud, Marina
Druesne-Pecollo, Nathalie
Partula, Valentin
Hercberg, Serge
Galan, Pilar
Cohen, Patrice
Hoarau, Hélène
Latino-Martel, Paule
Srour, Bernard
Gonzalez, Rebeca
Deschasaux, Mélanie
Touvier, Mathilde
author_facet Fassier, Philippine
Zelek, Laurent
Bachmann, Patrick
Touillaud, Marina
Druesne-Pecollo, Nathalie
Partula, Valentin
Hercberg, Serge
Galan, Pilar
Cohen, Patrice
Hoarau, Hélène
Latino-Martel, Paule
Srour, Bernard
Gonzalez, Rebeca
Deschasaux, Mélanie
Touvier, Mathilde
author_sort Fassier, Philippine
collection PubMed
description PURPOSE: While many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic, economic, lifestyle and clinical factors associated with moderate-to-severe weight gain. METHODS: 1051 incident cases of first primary cancer were diagnosed in the NutriNet-Santé cohort between 2009 and 2015. Weight was prospectively collected every 6 months since subjects’ inclusion (i.e. an average of 2y before diagnosis). Mean weights before and after cancer diagnosis were compared with paired Student's t-test. Factors associated with moderate-to-severe weight gain (≥5% of initial weight) were investigated by age and sex-adjusted logistic regression. RESULTS: Weight loss was observed in men (-3.54±4.39kg in those who lost weight, p=0.0002) and in colorectal cancer patients (-3.94±4.40kg, p=0.001). Weight gain was observed in breast and skin cancers (2.83±3.21kg, p=0.04, and 2.96±2.75kg, p=0.04 respectively). Women (OR=1.75[1.06-2.87],p=0.03), younger patients (2.44[1.51-3.70],p<0.0001), those with lower income (OR=1.30[1.01-1.72],p-trend=0.007), lower education (OR=1.32[1.03-2.70],p-trend=0.03), excess weight before diagnosis (OR=1.64[1.12-2.42],p=0.01), lower physical activity (OR=1.28[1.01-1.64],p=0.04) and those who stopped smoking (OR=4.31[1.99-9.35],p=0.005]) were more likely to gain weight. In breast cancer patients, induced menopause was associated with weight gain (OR=4.12[1.76-9.67]), but no association was detected for tumor characteristics or treatments. CONCLUSION: This large prospective cohort provided original results on weight variation between before and after cancer diagnosis, highlighting different weight trajectories. Socio-demographic and economic factors appeared to influence the risk of weight gain, illustrating social inequalities in health.
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spelling pubmed-55896102017-09-12 Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort Fassier, Philippine Zelek, Laurent Bachmann, Patrick Touillaud, Marina Druesne-Pecollo, Nathalie Partula, Valentin Hercberg, Serge Galan, Pilar Cohen, Patrice Hoarau, Hélène Latino-Martel, Paule Srour, Bernard Gonzalez, Rebeca Deschasaux, Mélanie Touvier, Mathilde Oncotarget Research Paper PURPOSE: While many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic, economic, lifestyle and clinical factors associated with moderate-to-severe weight gain. METHODS: 1051 incident cases of first primary cancer were diagnosed in the NutriNet-Santé cohort between 2009 and 2015. Weight was prospectively collected every 6 months since subjects’ inclusion (i.e. an average of 2y before diagnosis). Mean weights before and after cancer diagnosis were compared with paired Student's t-test. Factors associated with moderate-to-severe weight gain (≥5% of initial weight) were investigated by age and sex-adjusted logistic regression. RESULTS: Weight loss was observed in men (-3.54±4.39kg in those who lost weight, p=0.0002) and in colorectal cancer patients (-3.94±4.40kg, p=0.001). Weight gain was observed in breast and skin cancers (2.83±3.21kg, p=0.04, and 2.96±2.75kg, p=0.04 respectively). Women (OR=1.75[1.06-2.87],p=0.03), younger patients (2.44[1.51-3.70],p<0.0001), those with lower income (OR=1.30[1.01-1.72],p-trend=0.007), lower education (OR=1.32[1.03-2.70],p-trend=0.03), excess weight before diagnosis (OR=1.64[1.12-2.42],p=0.01), lower physical activity (OR=1.28[1.01-1.64],p=0.04) and those who stopped smoking (OR=4.31[1.99-9.35],p=0.005]) were more likely to gain weight. In breast cancer patients, induced menopause was associated with weight gain (OR=4.12[1.76-9.67]), but no association was detected for tumor characteristics or treatments. CONCLUSION: This large prospective cohort provided original results on weight variation between before and after cancer diagnosis, highlighting different weight trajectories. Socio-demographic and economic factors appeared to influence the risk of weight gain, illustrating social inequalities in health. Impact Journals LLC 2017-05-08 /pmc/articles/PMC5589610/ /pubmed/28903371 http://dx.doi.org/10.18632/oncotarget.17676 Text en Copyright: © 2017 Fassier et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Fassier, Philippine
Zelek, Laurent
Bachmann, Patrick
Touillaud, Marina
Druesne-Pecollo, Nathalie
Partula, Valentin
Hercberg, Serge
Galan, Pilar
Cohen, Patrice
Hoarau, Hélène
Latino-Martel, Paule
Srour, Bernard
Gonzalez, Rebeca
Deschasaux, Mélanie
Touvier, Mathilde
Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title_full Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title_fullStr Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title_full_unstemmed Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title_short Sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based NutriNet-Santé cohort
title_sort sociodemographic and economic factors are associated with weight gain between before and after cancer diagnosis: results from the prospective population-based nutrinet-santé cohort
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589610/
https://www.ncbi.nlm.nih.gov/pubmed/28903371
http://dx.doi.org/10.18632/oncotarget.17676
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