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Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population
BACKGROUND: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. METHODS: This hospital-based, case-control stu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589622/ https://www.ncbi.nlm.nih.gov/pubmed/28903383 http://dx.doi.org/10.18632/oncotarget.18592 |
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author | Ben, Qiwen Liu, Jun Wang, Weiyi Guo, Fang Yao, Weiyan Zhong, Jie Yuan, Yaozong |
author_facet | Ben, Qiwen Liu, Jun Wang, Weiyi Guo, Fang Yao, Weiyan Zhong, Jie Yuan, Yaozong |
author_sort | Ben, Qiwen |
collection | PubMed |
description | BACKGROUND: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. METHODS: This hospital-based, case-control study included 387 patients with PNET and 542 age- and sex-matched controls. Unconditional multivariable logistic regression analysis was performed to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs). The relationship between ABO blood types and clinicopathologic features was also analyzed. RESULTS: After adjusting for age, sex, smoking status, alcohol drinking, and first-degree family history of any cancer, the AORs (95% CI) of functional PNET were 0.87 (0.59–1.28) for blood type A, 0.86 (0.58–1.28) for blood type B, and 0.71 (0.39–1.26) for blood type AB compared with subjects with blood type O. A similar ABO blood-type distribution was observed among cases with non-functional PNETs compared with controls. On comparing blood type B with non-B blood type, cases with non-functional PNETs had marginally higher rates of lymph node invasion (P = 0.047), distant metastasis (P = 0.044), and advanced European Neuroendocrine Tumor Society Stage (P = 0.040). CONCLUSIONS: There is no association between the ABO blood group and the development of functional and non-functional PNETs. The ABO blood types are not associated with the clinicopathologic features in patients with functional and non-functional PNETs. |
format | Online Article Text |
id | pubmed-5589622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55896222017-09-12 Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population Ben, Qiwen Liu, Jun Wang, Weiyi Guo, Fang Yao, Weiyan Zhong, Jie Yuan, Yaozong Oncotarget Research Paper BACKGROUND: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. METHODS: This hospital-based, case-control study included 387 patients with PNET and 542 age- and sex-matched controls. Unconditional multivariable logistic regression analysis was performed to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs). The relationship between ABO blood types and clinicopathologic features was also analyzed. RESULTS: After adjusting for age, sex, smoking status, alcohol drinking, and first-degree family history of any cancer, the AORs (95% CI) of functional PNET were 0.87 (0.59–1.28) for blood type A, 0.86 (0.58–1.28) for blood type B, and 0.71 (0.39–1.26) for blood type AB compared with subjects with blood type O. A similar ABO blood-type distribution was observed among cases with non-functional PNETs compared with controls. On comparing blood type B with non-B blood type, cases with non-functional PNETs had marginally higher rates of lymph node invasion (P = 0.047), distant metastasis (P = 0.044), and advanced European Neuroendocrine Tumor Society Stage (P = 0.040). CONCLUSIONS: There is no association between the ABO blood group and the development of functional and non-functional PNETs. The ABO blood types are not associated with the clinicopathologic features in patients with functional and non-functional PNETs. Impact Journals LLC 2017-06-21 /pmc/articles/PMC5589622/ /pubmed/28903383 http://dx.doi.org/10.18632/oncotarget.18592 Text en Copyright: © 2017 Ben et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ben, Qiwen Liu, Jun Wang, Weiyi Guo, Fang Yao, Weiyan Zhong, Jie Yuan, Yaozong Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title | Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title_full | Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title_fullStr | Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title_full_unstemmed | Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title_short | Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population |
title_sort | association between abo blood types and sporadic pancreatic neuroendocrine tumors in the chinese han population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589622/ https://www.ncbi.nlm.nih.gov/pubmed/28903383 http://dx.doi.org/10.18632/oncotarget.18592 |
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