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Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers
Aurora kinase A (AURKA) is a serine threonine kinase which affects chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. Two functional nonsynonymous polymorphisms of the AURKA gene (Ile31Phe and Val57Ile) have been reported recently. We analyze...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589629/ https://www.ncbi.nlm.nih.gov/pubmed/28903390 http://dx.doi.org/10.18632/oncotarget.18613 |
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author | Bao, Zhiyu Lu, Lei Liu, Xinyi Guo, Bingqian Zhai, Yun Li, Yuanfeng Wang, Yahui Xie, Bobo Ren, Qian Cao, Pengbo Han, Yuqing Jia, Weihua Chen, Minshan Liang, Xinqiang Wang, Xuan Zeng, Yi-Xin He, Fuchu Zhang, Hongxing Cui, Ying Zhou, Gangqiao |
author_facet | Bao, Zhiyu Lu, Lei Liu, Xinyi Guo, Bingqian Zhai, Yun Li, Yuanfeng Wang, Yahui Xie, Bobo Ren, Qian Cao, Pengbo Han, Yuqing Jia, Weihua Chen, Minshan Liang, Xinqiang Wang, Xuan Zeng, Yi-Xin He, Fuchu Zhang, Hongxing Cui, Ying Zhou, Gangqiao |
author_sort | Bao, Zhiyu |
collection | PubMed |
description | Aurora kinase A (AURKA) is a serine threonine kinase which affects chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. Two functional nonsynonymous polymorphisms of the AURKA gene (Ile31Phe and Val57Ile) have been reported recently. We analyzed the association between the two polymorphisms and risk of the occurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Guangxi population consisting of 348 patients with HCC and 359 control subjects, and then validated the significant association in the Guangdong population consisting of 440 cases and 456 controls. All of the participants were of Chinese origin and HBV carriers. The two polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay or Sequenom MassARRAY iPLEX platform. In the Guangxi population, carriers of the AURKA 31Phe allele (Ile/Phe + Phe/Phe) were significantly associated with decreased susceptibility to HBV-related HCC when compared with noncarriers (Ile/Ile) (odds ratio [OR] = 0.63, 95% confidence interval [CI] = 0.46-0.86, P = 3.4 × 10(-3)). On the contrary, no significant association was found between Val57Ile and HBV-related HCC occurrence. The association of Ile31Phe with HBV-related HCC occurrence was confirmed in the Guangdong population (OR = 0.64, 95% CI = 0.49-0.83, P = 8.0 × 10(-4)). The pooled analysis gave a joint P value of 5.5 × 10(-6) (joint OR = 0.63, 95% CI = 0.52-0.77). Our findings suggest that AURKA Ile31Phe may play a role in mediating the susceptibility to HBV-related HCC among Chinese. |
format | Online Article Text |
id | pubmed-5589629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55896292017-09-12 Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers Bao, Zhiyu Lu, Lei Liu, Xinyi Guo, Bingqian Zhai, Yun Li, Yuanfeng Wang, Yahui Xie, Bobo Ren, Qian Cao, Pengbo Han, Yuqing Jia, Weihua Chen, Minshan Liang, Xinqiang Wang, Xuan Zeng, Yi-Xin He, Fuchu Zhang, Hongxing Cui, Ying Zhou, Gangqiao Oncotarget Research Paper Aurora kinase A (AURKA) is a serine threonine kinase which affects chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. Two functional nonsynonymous polymorphisms of the AURKA gene (Ile31Phe and Val57Ile) have been reported recently. We analyzed the association between the two polymorphisms and risk of the occurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Guangxi population consisting of 348 patients with HCC and 359 control subjects, and then validated the significant association in the Guangdong population consisting of 440 cases and 456 controls. All of the participants were of Chinese origin and HBV carriers. The two polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay or Sequenom MassARRAY iPLEX platform. In the Guangxi population, carriers of the AURKA 31Phe allele (Ile/Phe + Phe/Phe) were significantly associated with decreased susceptibility to HBV-related HCC when compared with noncarriers (Ile/Ile) (odds ratio [OR] = 0.63, 95% confidence interval [CI] = 0.46-0.86, P = 3.4 × 10(-3)). On the contrary, no significant association was found between Val57Ile and HBV-related HCC occurrence. The association of Ile31Phe with HBV-related HCC occurrence was confirmed in the Guangdong population (OR = 0.64, 95% CI = 0.49-0.83, P = 8.0 × 10(-4)). The pooled analysis gave a joint P value of 5.5 × 10(-6) (joint OR = 0.63, 95% CI = 0.52-0.77). Our findings suggest that AURKA Ile31Phe may play a role in mediating the susceptibility to HBV-related HCC among Chinese. Impact Journals LLC 2017-06-27 /pmc/articles/PMC5589629/ /pubmed/28903390 http://dx.doi.org/10.18632/oncotarget.18613 Text en Copyright: © 2017 Bao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Bao, Zhiyu Lu, Lei Liu, Xinyi Guo, Bingqian Zhai, Yun Li, Yuanfeng Wang, Yahui Xie, Bobo Ren, Qian Cao, Pengbo Han, Yuqing Jia, Weihua Chen, Minshan Liang, Xinqiang Wang, Xuan Zeng, Yi-Xin He, Fuchu Zhang, Hongxing Cui, Ying Zhou, Gangqiao Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title | Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title_full | Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title_fullStr | Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title_full_unstemmed | Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title_short | Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers |
title_sort | association between the functional polymorphism ile31phe in the aurka gene and susceptibility of hepatocellular carcinoma in chronic hepatitis b virus carriers |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589629/ https://www.ncbi.nlm.nih.gov/pubmed/28903390 http://dx.doi.org/10.18632/oncotarget.18613 |
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