Cargando…

Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis

BACKGROUND AND AIM: Recent epidemiological studies indicated that metformin might improve the survival of various cancers. However, its benefit on pancreatic cancer was controversial. METHODS: We performed this meta-analysis to investigate the benefit of metformin on pancreatic cancer. A comprehensi...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Yi-Wei, Shi, Yan-Qiang, He, Li-Wen, Cui, Xi-Yu, Su, Pei-Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589674/
https://www.ncbi.nlm.nih.gov/pubmed/28903435
http://dx.doi.org/10.18632/oncotarget.18233
_version_ 1783262381618495488
author Dong, Yi-Wei
Shi, Yan-Qiang
He, Li-Wen
Cui, Xi-Yu
Su, Pei-Zhu
author_facet Dong, Yi-Wei
Shi, Yan-Qiang
He, Li-Wen
Cui, Xi-Yu
Su, Pei-Zhu
author_sort Dong, Yi-Wei
collection PubMed
description BACKGROUND AND AIM: Recent epidemiological studies indicated that metformin might improve the survival of various cancers. However, its benefit on pancreatic cancer was controversial. METHODS: We performed this meta-analysis to investigate the benefit of metformin on pancreatic cancer. A comprehensive literature search was performed through PubMed, Cochrane Library and Embase. Relative risk (RR) and hazard ratio (HR) with 95% confidence interval (CI) were pooled. RESULTS: The meta-analysis of 2 randomized controlled trials including181 pancreatic patients, revealed that metformin use was not associated with an improved overall survival at 6 months (RR=0.90, 95% CI=0.67-1.21), overall survival (HR=1.19, 95% CI=0.86-1.63) and progression-free survival (HR=1.39, 95% CI=0.97-1.99). But the meta-analysis of 8 cohorts, involving 2805 pancreatic patients with diabetes, demonstrated a favorable result with improved overall survival (HR=0.78, 95% CI=0.66-0.92). CONCLUSIONS: Observations in the cohort studies supported a favorable role of metformin while the data from randomized controlled trials did not support that. Therefore, more high-quality RCTs are warranted.
format Online
Article
Text
id pubmed-5589674
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-55896742017-09-12 Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis Dong, Yi-Wei Shi, Yan-Qiang He, Li-Wen Cui, Xi-Yu Su, Pei-Zhu Oncotarget Meta-Analysis BACKGROUND AND AIM: Recent epidemiological studies indicated that metformin might improve the survival of various cancers. However, its benefit on pancreatic cancer was controversial. METHODS: We performed this meta-analysis to investigate the benefit of metformin on pancreatic cancer. A comprehensive literature search was performed through PubMed, Cochrane Library and Embase. Relative risk (RR) and hazard ratio (HR) with 95% confidence interval (CI) were pooled. RESULTS: The meta-analysis of 2 randomized controlled trials including181 pancreatic patients, revealed that metformin use was not associated with an improved overall survival at 6 months (RR=0.90, 95% CI=0.67-1.21), overall survival (HR=1.19, 95% CI=0.86-1.63) and progression-free survival (HR=1.39, 95% CI=0.97-1.99). But the meta-analysis of 8 cohorts, involving 2805 pancreatic patients with diabetes, demonstrated a favorable result with improved overall survival (HR=0.78, 95% CI=0.66-0.92). CONCLUSIONS: Observations in the cohort studies supported a favorable role of metformin while the data from randomized controlled trials did not support that. Therefore, more high-quality RCTs are warranted. Impact Journals LLC 2017-05-26 /pmc/articles/PMC5589674/ /pubmed/28903435 http://dx.doi.org/10.18632/oncotarget.18233 Text en Copyright: © 2017 Dong et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Dong, Yi-Wei
Shi, Yan-Qiang
He, Li-Wen
Cui, Xi-Yu
Su, Pei-Zhu
Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title_full Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title_fullStr Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title_full_unstemmed Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title_short Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
title_sort effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589674/
https://www.ncbi.nlm.nih.gov/pubmed/28903435
http://dx.doi.org/10.18632/oncotarget.18233
work_keys_str_mv AT dongyiwei effectsofmetforminonsurvivaloutcomesofpancreaticcancerametaanalysis
AT shiyanqiang effectsofmetforminonsurvivaloutcomesofpancreaticcancerametaanalysis
AT heliwen effectsofmetforminonsurvivaloutcomesofpancreaticcancerametaanalysis
AT cuixiyu effectsofmetforminonsurvivaloutcomesofpancreaticcancerametaanalysis
AT supeizhu effectsofmetforminonsurvivaloutcomesofpancreaticcancerametaanalysis