Tissue alkalosis in cold-ischemia time

The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polyn...

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Detalles Bibliográficos
Autores principales: Denninghoff, V., Olivieri, E. H. R., Fresno, C., Uceda, A., Mota, L., Suenaga, A. P., Carraro, D. M., Martins, V. R., Avagnina, A., Soares, F. A., Campos, A. H. J. Fróes Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589730/
https://www.ncbi.nlm.nih.gov/pubmed/28883635
http://dx.doi.org/10.1038/s41598-017-11284-z
Descripción
Sumario:The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.

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