Tissue alkalosis in cold-ischemia time

The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polyn...

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Autores principales: Denninghoff, V., Olivieri, E. H. R., Fresno, C., Uceda, A., Mota, L., Suenaga, A. P., Carraro, D. M., Martins, V. R., Avagnina, A., Soares, F. A., Campos, A. H. J. Fróes Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589730/
https://www.ncbi.nlm.nih.gov/pubmed/28883635
http://dx.doi.org/10.1038/s41598-017-11284-z
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author Denninghoff, V.
Olivieri, E. H. R.
Fresno, C.
Uceda, A.
Mota, L.
Suenaga, A. P.
Carraro, D. M.
Martins, V. R.
Avagnina, A.
Soares, F. A.
Campos, A. H. J. Fróes Marques
author_facet Denninghoff, V.
Olivieri, E. H. R.
Fresno, C.
Uceda, A.
Mota, L.
Suenaga, A. P.
Carraro, D. M.
Martins, V. R.
Avagnina, A.
Soares, F. A.
Campos, A. H. J. Fróes Marques
author_sort Denninghoff, V.
collection PubMed
description The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.
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spelling pubmed-55897302017-09-13 Tissue alkalosis in cold-ischemia time Denninghoff, V. Olivieri, E. H. R. Fresno, C. Uceda, A. Mota, L. Suenaga, A. P. Carraro, D. M. Martins, V. R. Avagnina, A. Soares, F. A. Campos, A. H. J. Fróes Marques Sci Rep Article The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples. Nature Publishing Group UK 2017-09-07 /pmc/articles/PMC5589730/ /pubmed/28883635 http://dx.doi.org/10.1038/s41598-017-11284-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Denninghoff, V.
Olivieri, E. H. R.
Fresno, C.
Uceda, A.
Mota, L.
Suenaga, A. P.
Carraro, D. M.
Martins, V. R.
Avagnina, A.
Soares, F. A.
Campos, A. H. J. Fróes Marques
Tissue alkalosis in cold-ischemia time
title Tissue alkalosis in cold-ischemia time
title_full Tissue alkalosis in cold-ischemia time
title_fullStr Tissue alkalosis in cold-ischemia time
title_full_unstemmed Tissue alkalosis in cold-ischemia time
title_short Tissue alkalosis in cold-ischemia time
title_sort tissue alkalosis in cold-ischemia time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589730/
https://www.ncbi.nlm.nih.gov/pubmed/28883635
http://dx.doi.org/10.1038/s41598-017-11284-z
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