Tau exacerbates excitotoxic brain damage in an animal model of stroke

Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau(−/−)) mice are profoundly protected from excitotoxic brain damage and neurological deficits following experimental stroke, using a middle cere...

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Detalles Bibliográficos
Autores principales: Bi, Mian, Gladbach, Amadeus, van Eersel, Janet, Ittner, Arne, Przybyla, Magdalena, van Hummel, Annika, Chua, Sook Wern, van der Hoven, Julia, Lee, Wei S., Müller, Julius, Parmar, Jasneet, Jonquieres, Georg von, Stefen, Holly, Guccione, Ernesto, Fath, Thomas, Housley, Gary D., Klugmann, Matthias, Ke, Yazi D., Ittner, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589746/
https://www.ncbi.nlm.nih.gov/pubmed/28883427
http://dx.doi.org/10.1038/s41467-017-00618-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589746/
https://www.ncbi.nlm.nih.gov/pubmed/28883427
http://dx.doi.org/10.1038/s41467-017-00618-0

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