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Reovirus inhibits interferon production by sequestering IRF3 into viral factories

Upon viral infection, an arms-race between the cellular intrinsic innate immune system and viral replication is established. To win this race, viruses have established multiple strategies to inhibit the cellular response. Mammalian reovirus (MRV) constitutes a great model to study pathogenesis and l...

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Detalles Bibliográficos
Autores principales: Stanifer, Megan L., Kischnick, Christian, Rippert, Anja, Albrecht, Dorothee, Boulant, Steeve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589761/
https://www.ncbi.nlm.nih.gov/pubmed/28883463
http://dx.doi.org/10.1038/s41598-017-11469-6