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White matter hyperintensity reduction and outcomes after minor stroke

OBJECTIVE: To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. METHODS: We recruited participants with minor ischemic stroke and performed clinica...

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Autores principales: Wardlaw, Joanna M., Chappell, Francesca M., Valdés Hernández, Maria del Carmen, Makin, Stephen D.J., Staals, Julie, Shuler, Kirsten, Thrippleton, Michael J., Armitage, Paul A., Muñoz-Maniega, Susana, Heye, Anna K., Sakka, Eleni, Dennis, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589793/
https://www.ncbi.nlm.nih.gov/pubmed/28794252
http://dx.doi.org/10.1212/WNL.0000000000004328
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author Wardlaw, Joanna M.
Chappell, Francesca M.
Valdés Hernández, Maria del Carmen
Makin, Stephen D.J.
Staals, Julie
Shuler, Kirsten
Thrippleton, Michael J.
Armitage, Paul A.
Muñoz-Maniega, Susana
Heye, Anna K.
Sakka, Eleni
Dennis, Martin S.
author_facet Wardlaw, Joanna M.
Chappell, Francesca M.
Valdés Hernández, Maria del Carmen
Makin, Stephen D.J.
Staals, Julie
Shuler, Kirsten
Thrippleton, Michael J.
Armitage, Paul A.
Muñoz-Maniega, Susana
Heye, Anna K.
Sakka, Eleni
Dennis, Martin S.
author_sort Wardlaw, Joanna M.
collection PubMed
description OBJECTIVE: To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. METHODS: We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI. At 1 year, we assessed recurrent cerebrovascular events and dependency and repeated the MRI. We assessed change in WMH volume from baseline to 1 year (normalized to percent intracranial volume [ICV]) and associations with baseline variables, clinical outcomes, and imaging parameters using multivariable analysis of covariance, model of changes, and multinomial logistic regression. RESULTS: Among 190 participants (mean age 65.3 years, range 34.3–96.9 years, 112 [59%] male), WMH decreased in 71 participants by 1 year. At baseline, participants whose WMH decreased had similar WMH volumes but higher blood pressure (p = 0.0064) compared with participants whose WMH increased. At 1 year, participants with WMH decrease (expressed as percent ICV) had larger reductions in blood pressure (β = 0.0053, 95% confidence interval [CI] 0.00099–0.0097 fewer WMH per 1–mm Hg decrease, p = 0.017) and in mean diffusivity in normal-appearing white matter (β = 0.075, 95% CI 0.0025–0.15 fewer WMH per 1-unit mean diffusivity decrease, p = 0.043) than participants with WMH increase; those with WMH increase experienced more recurrent cerebrovascular events (32%, vs 16% with WMH decrease, β = 0.27, 95% CI 0.047–0.50 more WMH per event, p = 0.018). CONCLUSIONS: Some WMH may regress after minor stroke, with potentially better clinical and brain tissue outcomes. The role of risk factor control requires verification. Interstitial fluid alterations may account for some WMH reversibility, offering potential intervention targets.
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spelling pubmed-55897932017-09-13 White matter hyperintensity reduction and outcomes after minor stroke Wardlaw, Joanna M. Chappell, Francesca M. Valdés Hernández, Maria del Carmen Makin, Stephen D.J. Staals, Julie Shuler, Kirsten Thrippleton, Michael J. Armitage, Paul A. Muñoz-Maniega, Susana Heye, Anna K. Sakka, Eleni Dennis, Martin S. Neurology Article OBJECTIVE: To assess factors associated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. METHODS: We recruited participants with minor ischemic stroke and performed clinical assessments and brain MRI. At 1 year, we assessed recurrent cerebrovascular events and dependency and repeated the MRI. We assessed change in WMH volume from baseline to 1 year (normalized to percent intracranial volume [ICV]) and associations with baseline variables, clinical outcomes, and imaging parameters using multivariable analysis of covariance, model of changes, and multinomial logistic regression. RESULTS: Among 190 participants (mean age 65.3 years, range 34.3–96.9 years, 112 [59%] male), WMH decreased in 71 participants by 1 year. At baseline, participants whose WMH decreased had similar WMH volumes but higher blood pressure (p = 0.0064) compared with participants whose WMH increased. At 1 year, participants with WMH decrease (expressed as percent ICV) had larger reductions in blood pressure (β = 0.0053, 95% confidence interval [CI] 0.00099–0.0097 fewer WMH per 1–mm Hg decrease, p = 0.017) and in mean diffusivity in normal-appearing white matter (β = 0.075, 95% CI 0.0025–0.15 fewer WMH per 1-unit mean diffusivity decrease, p = 0.043) than participants with WMH increase; those with WMH increase experienced more recurrent cerebrovascular events (32%, vs 16% with WMH decrease, β = 0.27, 95% CI 0.047–0.50 more WMH per event, p = 0.018). CONCLUSIONS: Some WMH may regress after minor stroke, with potentially better clinical and brain tissue outcomes. The role of risk factor control requires verification. Interstitial fluid alterations may account for some WMH reversibility, offering potential intervention targets. Lippincott Williams & Wilkins 2017-09-05 /pmc/articles/PMC5589793/ /pubmed/28794252 http://dx.doi.org/10.1212/WNL.0000000000004328 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Wardlaw, Joanna M.
Chappell, Francesca M.
Valdés Hernández, Maria del Carmen
Makin, Stephen D.J.
Staals, Julie
Shuler, Kirsten
Thrippleton, Michael J.
Armitage, Paul A.
Muñoz-Maniega, Susana
Heye, Anna K.
Sakka, Eleni
Dennis, Martin S.
White matter hyperintensity reduction and outcomes after minor stroke
title White matter hyperintensity reduction and outcomes after minor stroke
title_full White matter hyperintensity reduction and outcomes after minor stroke
title_fullStr White matter hyperintensity reduction and outcomes after minor stroke
title_full_unstemmed White matter hyperintensity reduction and outcomes after minor stroke
title_short White matter hyperintensity reduction and outcomes after minor stroke
title_sort white matter hyperintensity reduction and outcomes after minor stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589793/
https://www.ncbi.nlm.nih.gov/pubmed/28794252
http://dx.doi.org/10.1212/WNL.0000000000004328
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