Cargando…
Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons
Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589841/ https://www.ncbi.nlm.nih.gov/pubmed/28883658 http://dx.doi.org/10.1038/s41598-017-11268-z |
_version_ | 1783262416870572032 |
---|---|
author | Sah, Nirnath Peterson, Benjamin D. Lubejko, Susan T. Vivar, Carmen van Praag, Henriette |
author_facet | Sah, Nirnath Peterson, Benjamin D. Lubejko, Susan T. Vivar, Carmen van Praag, Henriette |
author_sort | Sah, Nirnath |
collection | PubMed |
description | Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells. Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7–8 days post retroviral injection (dpi) show that these cells respond to NMDA application with tonic currents, and that both electrical and optogenetic stimulation can evoke NMDA-mediated synaptic responses. Furthermore, new dentate granule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel running. Overall, glutamatergic and GABAergic innervation of newly born neurons in the adult hippocampus develops concurrently, and excitatory input is reorganized by exercise. |
format | Online Article Text |
id | pubmed-5589841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55898412017-09-13 Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons Sah, Nirnath Peterson, Benjamin D. Lubejko, Susan T. Vivar, Carmen van Praag, Henriette Sci Rep Article Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells. Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7–8 days post retroviral injection (dpi) show that these cells respond to NMDA application with tonic currents, and that both electrical and optogenetic stimulation can evoke NMDA-mediated synaptic responses. Furthermore, new dentate granule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel running. Overall, glutamatergic and GABAergic innervation of newly born neurons in the adult hippocampus develops concurrently, and excitatory input is reorganized by exercise. Nature Publishing Group UK 2017-09-07 /pmc/articles/PMC5589841/ /pubmed/28883658 http://dx.doi.org/10.1038/s41598-017-11268-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sah, Nirnath Peterson, Benjamin D. Lubejko, Susan T. Vivar, Carmen van Praag, Henriette Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title | Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title_full | Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title_fullStr | Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title_full_unstemmed | Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title_short | Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
title_sort | running reorganizes the circuitry of one-week-old adult-born hippocampal neurons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589841/ https://www.ncbi.nlm.nih.gov/pubmed/28883658 http://dx.doi.org/10.1038/s41598-017-11268-z |
work_keys_str_mv | AT sahnirnath runningreorganizesthecircuitryofoneweekoldadultbornhippocampalneurons AT petersonbenjamind runningreorganizesthecircuitryofoneweekoldadultbornhippocampalneurons AT lubejkosusant runningreorganizesthecircuitryofoneweekoldadultbornhippocampalneurons AT vivarcarmen runningreorganizesthecircuitryofoneweekoldadultbornhippocampalneurons AT vanpraaghenriette runningreorganizesthecircuitryofoneweekoldadultbornhippocampalneurons |