Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages

Macrophages (MΦs) with mutations in cystic fibrosis transmembrane conductance regulator (CFTR) have blunted induction of PI3K/AKT signaling in response to TLR4 activation, leading to hyperinflammation, a hallmark of cystic fibrosis (CF) disease. Here, we show that Ezrin links CFTR and TLR4 signaling...

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Detalles Bibliográficos
Autores principales: Di Pietro, Caterina, Zhang, Ping-xia, O’Rourke, Timothy K., Murray, Thomas S., Wang, Lin, Britto, Clemente J., Koff, Jonathan L., Krause, Diane S., Egan, Marie E., Bruscia, Emanuela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589856/
https://www.ncbi.nlm.nih.gov/pubmed/28883468
http://dx.doi.org/10.1038/s41598-017-11012-7

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