Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

BACKGROUND: Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hype...

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Detalles Bibliográficos
Autores principales: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Heilos, Daniela, Gabler, Lisa, van Schoonhoven, Sushilla, Terenzi, Alessio, Moser, Patrick, Pirker, Christine, Timelthaler, Gerald, Jäger, Walter, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590147/
https://www.ncbi.nlm.nih.gov/pubmed/28882160
http://dx.doi.org/10.1186/s13046-017-0592-3

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