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Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

BACKGROUND: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the dise...

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Autores principales: Jeong, Hyemin, Bae, Eun-Kyung, Kim, Hunnyun, Eun, Yeong Hee, Kim, In Young, Kim, Hyungjin, Lee, Jaejoon, Jeon, Chan Hong, Koh, Eun-Mi, Cha, Hoon-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590166/
https://www.ncbi.nlm.nih.gov/pubmed/28882159
http://dx.doi.org/10.1186/s13075-017-1407-9
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author Jeong, Hyemin
Bae, Eun-Kyung
Kim, Hunnyun
Eun, Yeong Hee
Kim, In Young
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan Hong
Koh, Eun-Mi
Cha, Hoon-Suk
author_facet Jeong, Hyemin
Bae, Eun-Kyung
Kim, Hunnyun
Eun, Yeong Hee
Kim, In Young
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan Hong
Koh, Eun-Mi
Cha, Hoon-Suk
author_sort Jeong, Hyemin
collection PubMed
description BACKGROUND: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA). METHODS: The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and (18)F-fluorodeoxyglucose ((18)F-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured. RESULTS: E2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. (18)F-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-γ, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice. CONCLUSIONS: Estrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model.
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spelling pubmed-55901662017-09-14 Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model Jeong, Hyemin Bae, Eun-Kyung Kim, Hunnyun Eun, Yeong Hee Kim, In Young Kim, Hyungjin Lee, Jaejoon Jeon, Chan Hong Koh, Eun-Mi Cha, Hoon-Suk Arthritis Res Ther Research Article BACKGROUND: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA). METHODS: The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and (18)F-fluorodeoxyglucose ((18)F-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured. RESULTS: E2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. (18)F-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-γ, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice. CONCLUSIONS: Estrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model. BioMed Central 2017-09-07 2017 /pmc/articles/PMC5590166/ /pubmed/28882159 http://dx.doi.org/10.1186/s13075-017-1407-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Jeong, Hyemin
Bae, Eun-Kyung
Kim, Hunnyun
Eun, Yeong Hee
Kim, In Young
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan Hong
Koh, Eun-Mi
Cha, Hoon-Suk
Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title_full Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title_fullStr Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title_full_unstemmed Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title_short Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
title_sort estrogen attenuates the spondyloarthritis manifestations of the skg arthritis model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590166/
https://www.ncbi.nlm.nih.gov/pubmed/28882159
http://dx.doi.org/10.1186/s13075-017-1407-9
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