(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

BACKGROUND: Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients with NSCLC as a number of oncogenic drivers have been found. Crizot...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Xuanxuan, Guo, Guilong, Zou, Peng, Cui, Ri, Chen, Weiqian, Chen, Xi, Yin, Changtian, He, Wei, Vinothkumar, Rajamanickam, Yang, Fan, Zhang, Xiaohua, Liang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590185/
https://www.ncbi.nlm.nih.gov/pubmed/28882182
http://dx.doi.org/10.1186/s13046-017-0584-3

Ejemplares similares

Ejemplares similares