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Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs
Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590429/ https://www.ncbi.nlm.nih.gov/pubmed/28952490 http://dx.doi.org/10.3390/bioengineering4010011 |
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author | Acosta-Vélez, Giovanny F. Linsley, Chase S. Craig, Madison C. Wu, Benjamin M. |
author_facet | Acosta-Vélez, Giovanny F. Linsley, Chase S. Craig, Madison C. Wu, Benjamin M. |
author_sort | Acosta-Vélez, Giovanny F. |
collection | PubMed |
description | Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs. |
format | Online Article Text |
id | pubmed-5590429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55904292017-09-21 Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs Acosta-Vélez, Giovanny F. Linsley, Chase S. Craig, Madison C. Wu, Benjamin M. Bioengineering (Basel) Article Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs. MDPI 2017-01-28 /pmc/articles/PMC5590429/ /pubmed/28952490 http://dx.doi.org/10.3390/bioengineering4010011 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Acosta-Vélez, Giovanny F. Linsley, Chase S. Craig, Madison C. Wu, Benjamin M. Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title | Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title_full | Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title_fullStr | Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title_full_unstemmed | Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title_short | Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs |
title_sort | photocurable bioink for the inkjet 3d pharming of hydrophilic drugs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590429/ https://www.ncbi.nlm.nih.gov/pubmed/28952490 http://dx.doi.org/10.3390/bioengineering4010011 |
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