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Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle se...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590468/ https://www.ncbi.nlm.nih.gov/pubmed/28952516 http://dx.doi.org/10.3390/bioengineering4020037 |
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author | Pidaparti, Ramana M. Cartin, Charles Su, Guoguang |
author_facet | Pidaparti, Ramana M. Cartin, Charles Su, Guoguang |
author_sort | Pidaparti, Ramana M. |
collection | PubMed |
description | In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications. |
format | Online Article Text |
id | pubmed-5590468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55904682017-09-21 Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † Pidaparti, Ramana M. Cartin, Charles Su, Guoguang Bioengineering (Basel) Article In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications. MDPI 2017-04-25 /pmc/articles/PMC5590468/ /pubmed/28952516 http://dx.doi.org/10.3390/bioengineering4020037 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pidaparti, Ramana M. Cartin, Charles Su, Guoguang Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title | Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title_full | Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title_fullStr | Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title_full_unstemmed | Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title_short | Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † |
title_sort | bio-inspired multi-functional drug transport design concept and simulations † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590468/ https://www.ncbi.nlm.nih.gov/pubmed/28952516 http://dx.doi.org/10.3390/bioengineering4020037 |
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