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Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †

In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle se...

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Detalles Bibliográficos
Autores principales: Pidaparti, Ramana M., Cartin, Charles, Su, Guoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590468/
https://www.ncbi.nlm.nih.gov/pubmed/28952516
http://dx.doi.org/10.3390/bioengineering4020037
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author Pidaparti, Ramana M.
Cartin, Charles
Su, Guoguang
author_facet Pidaparti, Ramana M.
Cartin, Charles
Su, Guoguang
author_sort Pidaparti, Ramana M.
collection PubMed
description In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications.
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spelling pubmed-55904682017-09-21 Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations † Pidaparti, Ramana M. Cartin, Charles Su, Guoguang Bioengineering (Basel) Article In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications. MDPI 2017-04-25 /pmc/articles/PMC5590468/ /pubmed/28952516 http://dx.doi.org/10.3390/bioengineering4020037 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pidaparti, Ramana M.
Cartin, Charles
Su, Guoguang
Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title_full Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title_fullStr Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title_full_unstemmed Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title_short Bio-Inspired Multi-Functional Drug Transport Design Concept and Simulations †
title_sort bio-inspired multi-functional drug transport design concept and simulations †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590468/
https://www.ncbi.nlm.nih.gov/pubmed/28952516
http://dx.doi.org/10.3390/bioengineering4020037
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