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Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study

BACKGROUND: We conducted a multi‐modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in...

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Autores principales: Tewarie, Prejaas, Balk, Lisanne J., Hillebrand, Arjan, Steenwijk, Martijn D., Uitdehaag, Bernard M. J., Stam, Cornelis J., Petzold, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590521/
https://www.ncbi.nlm.nih.gov/pubmed/28904983
http://dx.doi.org/10.1002/acn3.415
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author Tewarie, Prejaas
Balk, Lisanne J.
Hillebrand, Arjan
Steenwijk, Martijn D.
Uitdehaag, Bernard M. J.
Stam, Cornelis J.
Petzold, Axel
author_facet Tewarie, Prejaas
Balk, Lisanne J.
Hillebrand, Arjan
Steenwijk, Martijn D.
Uitdehaag, Bernard M. J.
Stam, Cornelis J.
Petzold, Axel
author_sort Tewarie, Prejaas
collection PubMed
description BACKGROUND: We conducted a multi‐modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: One hundred and two MS patients were included in this MEG/OCT study. Retinal OCT data were collected from the optic discs, macular region, and segmented. Neuronal activity and FC in the visual cortex was estimated from source‐reconstructed resting‐state MEG data by computing relative power and the phase lag index (PLI). Generalized estimating equations (GEE) were used to account for intereye within‐patient dependencies. RESULTS: There was a significant relationship for both relative power and FC in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of MSON, particularly for connectivity in the alpha bands and the outer macular layers. In the absence of MSON, this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers. CONCLUSION: These results suggest that visual cortex FC more than activity alters in the presence of MSON, which may guide the understanding of FC plasticity effects following MSON.
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spelling pubmed-55905212017-09-13 Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study Tewarie, Prejaas Balk, Lisanne J. Hillebrand, Arjan Steenwijk, Martijn D. Uitdehaag, Bernard M. J. Stam, Cornelis J. Petzold, Axel Ann Clin Transl Neurol Research Articles BACKGROUND: We conducted a multi‐modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: One hundred and two MS patients were included in this MEG/OCT study. Retinal OCT data were collected from the optic discs, macular region, and segmented. Neuronal activity and FC in the visual cortex was estimated from source‐reconstructed resting‐state MEG data by computing relative power and the phase lag index (PLI). Generalized estimating equations (GEE) were used to account for intereye within‐patient dependencies. RESULTS: There was a significant relationship for both relative power and FC in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of MSON, particularly for connectivity in the alpha bands and the outer macular layers. In the absence of MSON, this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers. CONCLUSION: These results suggest that visual cortex FC more than activity alters in the presence of MSON, which may guide the understanding of FC plasticity effects following MSON. John Wiley and Sons Inc. 2017-07-25 /pmc/articles/PMC5590521/ /pubmed/28904983 http://dx.doi.org/10.1002/acn3.415 Text en © 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Tewarie, Prejaas
Balk, Lisanne J.
Hillebrand, Arjan
Steenwijk, Martijn D.
Uitdehaag, Bernard M. J.
Stam, Cornelis J.
Petzold, Axel
Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title_full Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title_fullStr Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title_full_unstemmed Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title_short Structure‐function relationships in the visual system in multiple sclerosis: an MEG and OCT study
title_sort structure‐function relationships in the visual system in multiple sclerosis: an meg and oct study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590521/
https://www.ncbi.nlm.nih.gov/pubmed/28904983
http://dx.doi.org/10.1002/acn3.415
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