Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (G6PD Mahidol Variant) versus G6PD-Normal Volunteers

Tafenoquine is an 8-aminoquinoline under investigation for the prevention of relapse in Plasmodium vivax malaria. This open-label, dose-escalation study assessed quantitatively the hemolytic risk with tafenoquine in female healthy volunteers heterozygous for the Mahidol(487A) glucose-6-phosphate deh...

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Detalles Bibliográficos
Autores principales: Rueangweerayut, Ronnatrai, Bancone, Germana, Harrell, Emma J., Beelen, Andrew P., Kongpatanakul, Supornchai, Möhrle, Jörg J., Rousell, Vicki, Mohamed, Khadeeja, Qureshi, Ammar, Narayan, Sushma, Yubon, Nushara, Miller, Ann, Nosten, François H., Luzzatto, Lucio, Duparc, Stephan, Kleim, Jörg-Peter, Green, Justin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590573/
https://www.ncbi.nlm.nih.gov/pubmed/28749773
http://dx.doi.org/10.4269/ajtmh.16-0779

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