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Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer
Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic act...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590696/ https://www.ncbi.nlm.nih.gov/pubmed/28912637 http://dx.doi.org/10.1177/1179555717729652 |
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author | Yoshizawa, Tadashi Ishido, Keinosuke Saito, Kensuke Haga, Toshihiro Seino, Hiroko Wu, Yunyan Morohashi, Satoko Hakamada, Kenichi Kijima, Hiroshi |
author_facet | Yoshizawa, Tadashi Ishido, Keinosuke Saito, Kensuke Haga, Toshihiro Seino, Hiroko Wu, Yunyan Morohashi, Satoko Hakamada, Kenichi Kijima, Hiroshi |
author_sort | Yoshizawa, Tadashi |
collection | PubMed |
description | Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy. |
format | Online Article Text |
id | pubmed-5590696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55906962017-09-14 Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer Yoshizawa, Tadashi Ishido, Keinosuke Saito, Kensuke Haga, Toshihiro Seino, Hiroko Wu, Yunyan Morohashi, Satoko Hakamada, Kenichi Kijima, Hiroshi Clin Med Insights Pathol Original Research Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy. SAGE Publications 2017-09-06 /pmc/articles/PMC5590696/ /pubmed/28912637 http://dx.doi.org/10.1177/1179555717729652 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Yoshizawa, Tadashi Ishido, Keinosuke Saito, Kensuke Haga, Toshihiro Seino, Hiroko Wu, Yunyan Morohashi, Satoko Hakamada, Kenichi Kijima, Hiroshi Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title | Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title_full | Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title_fullStr | Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title_full_unstemmed | Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title_short | Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
title_sort | prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in extrahepatic bile duct cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590696/ https://www.ncbi.nlm.nih.gov/pubmed/28912637 http://dx.doi.org/10.1177/1179555717729652 |
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