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Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin

BACKGROUND: Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed whether EFV dosing sh...

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Detalles Bibliográficos
Autores principales:	Soeria-Atmadja, Sandra, Österberg, Emma, Gustafsson, Lars L., Dahl, Marja-Liisa, Eriksen, Jaran, Rubin, Johanna, Navér, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590735/ https://www.ncbi.nlm.nih.gov/pubmed/28886044 http://dx.doi.org/10.1371/journal.pone.0181316

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