Cargando…

B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moura, Rita A., Quaresma, Cláudia, Vieira, Ana R., Gonçalves, Maria J., Polido-Pereira, Joaquim, Romão, Vasco C., Martins, Nádia, Canhão, Helena, Fonseca, João E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590747/ https://www.ncbi.nlm.nih.gov/pubmed/28886017 http://dx.doi.org/10.1371/journal.pone.0182927

Ejemplares similares

Reduced CD27(−)IgD(−) B Cells in Blood and Raised CD27(−)IgD(−) B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease
por: Pararasa, Chathyan, et al.
Publicado: (2019)

Impaired CD27(+)IgD(+) B Cells With Altered Gene Signature in Rheumatoid Arthritis
por: Hu, Fanlei, et al.
Publicado: (2018)

Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM(+)IgD(+)CD27(+) B Cells That Differ Phenotypically, Functionally, and Genetically
por: Bautista, Diana, et al.
Publicado: (2020)

T cell–independent development and induction of somatic hypermutation in human IgM(+)IgD(+)CD27(+) B cells
por: Scheeren, Ferenc A., et al.
Publicado: (2008)

Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells
Publicado: (1978)

Teleost IgD(+)IgM(−) B cells in gills and skin have a plasmablast profile, but functionally and phenotypically differ from IgM(+)IgD(−) B cells in these sites
por: Herranz-Jusdado, J. Germán, et al.
Publicado: (2023)

Comparative Effectiveness of Tocilizumab and TNF Inhibitors in Rheumatoid Arthritis Patients: Data from the Rheumatic Diseases Portuguese Register, Reuma.pt
por: C. Romão, Vasco, et al.
Publicado: (2015)

Double-negative (CD27(−)IgD(−)) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations
por: Centuori, Sara M., et al.
Publicado: (2018)

Molecular footprints of a germinal center derivation of human IgM(+)(IgD(+))CD27(+) B cells and the dynamics of memory B cell generation
por: Seifert, Marc, et al.
Publicado: (2009)

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells
Publicado: (1993)

Teleost IgD(+)IgM(−) B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles
por: Perdiguero, Pedro, et al.
Publicado: (2019)

Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM(+)IgD(+)CD27(+) B cell repertoire in infants
por: Weller, Sandra, et al.
Publicado: (2008)

Physiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies
Publicado: (1981)

CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males
por: Nevalainen, Tapio, et al.
Publicado: (2019)

Generation of plasma cells and CD27(−)IgD(−) B cells during hantavirus infection is associated with distinct pathological findings
por: Kerkman, Priscilla F, et al.
Publicado: (2021)

CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis
por: Mahmood, Zafar, et al.
Publicado: (2015)

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
por: Noviski, Mark, et al.
Publicado: (2018)

IgD attenuates the IgM-induced anergy response in transitional and mature B cells
por: Sabouri, Zahra, et al.
Publicado: (2016)

Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa
por: Corrado, Alessia, et al.
Publicado: (2021)

Ampk regulates IgD expression but not energy stress with B cell activation
por: Waters, Lynnea R., et al.
Publicado: (2019)

IgD shapes the pre-immune naïve B cell compartment in humans
por: Dirks, Johannes, et al.
Publicado: (2023)

Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
por: Asito, Amolo S, et al.
Publicado: (2011)

CD27(+)IgD(−) B cells in the peripheral blood of colorectal cancer patients: on anti-tumor or tumor-protective mission?
por: Jahrsdörfer, Bernd, et al.
Publicado: (2014)

Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice
Publicado: (1977)

Physiology of IgD. VI. Transfer of the immunoaugmenting effect of IgD with T delta-containing helper cell populations
Publicado: (1985)

Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells
Publicado: (1976)

Severity of SARS-CoV-2 infection is linked to double-negative (CD27(−) IgD(−)) B cell subset numbers
por: Cervantes-Díaz, Rodrigo, et al.
Publicado: (2021)

Mature IgD(low/-) B cells maintain tolerance by promoting regulatory T cell homeostasis
por: Ray, Avijit, et al.
Publicado: (2019)

B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells
por: Vitetta, ES, et al.
Publicado: (1977)

IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways
por: Han, Le, et al.
Publicado: (2020)

Regulation of T Cell Activities in Rheumatoid Arthritis by the Novel Fusion Protein IgD-Fc-Ig
por: Zhang, Jing, et al.
Publicado: (2020)

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors
por: Herzenberg, LA, et al.
Publicado: (1980)

Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas
Publicado: (1984)

CD19+IgD+CD27- Naïve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients
por: Schulz, Eduard, et al.
Publicado: (2021)

Increased frequency of IgD-CD27(hi)CD38(hi) B cells and its association with the renal involvement in ANCA-associated vasculitis
por: Wang, Chen, et al.
Publicado: (2022)

Human Immunoglobulin (Ig)M(+)IgD(+) Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells
por: Klein, Ulf, et al.
Publicado: (1998)

B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells
Publicado: (1977)

B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection
por: Baker, Pamela J., et al.
Publicado: (2009)

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR
por: Setz, Corinna S, et al.
Publicado: (2019)

Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients
por: Rodríguez-Bayona, Beatriz, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_devgpred2hk0qsnmcu2ep2liqp