Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells

PURPOSE: The primary cause of Cushing’s disease is adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. EGFR signaling induces POMC mRNA-transcript levels and ACTH secretion from corticotroph tumors. The Jak–STAT pathway is located downstream of EGFR signaling; therefore, a Jak2 inhibito...

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Detalles Bibliográficos
Autores principales: Asari, Yuko, Kageyama, Kazunori, Nakada, Yuki, Tasso, Mizuki, Takayasu, Shinobu, Niioka, Kanako, Ishigame, Noriko, Daimon, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590765/
https://www.ncbi.nlm.nih.gov/pubmed/28919782
http://dx.doi.org/10.2147/OTT.S141345

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