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Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis

Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular s...

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Autores principales: Lim, Chae Jin, Lee, Yong-Moon, Kang, Seung Goo, Lim, Hyung W., Shin, Kyong-Oh, Jeong, Se Kyoo, Huh, Yang Hoon, Choi, Suin, Kor, Myungho, Seo, Ho Seong, Park, Byeong Deog, Park, Keedon, Ahn, Jeong Keun, Uchida, Yoshikazu, Park, Kyungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590795/
https://www.ncbi.nlm.nih.gov/pubmed/28822991
http://dx.doi.org/10.4062/biomolther.2017.119
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author Lim, Chae Jin
Lee, Yong-Moon
Kang, Seung Goo
Lim, Hyung W.
Shin, Kyong-Oh
Jeong, Se Kyoo
Huh, Yang Hoon
Choi, Suin
Kor, Myungho
Seo, Ho Seong
Park, Byeong Deog
Park, Keedon
Ahn, Jeong Keun
Uchida, Yoshikazu
Park, Kyungho
author_facet Lim, Chae Jin
Lee, Yong-Moon
Kang, Seung Goo
Lim, Hyung W.
Shin, Kyong-Oh
Jeong, Se Kyoo
Huh, Yang Hoon
Choi, Suin
Kor, Myungho
Seo, Ho Seong
Park, Byeong Deog
Park, Keedon
Ahn, Jeong Keun
Uchida, Yoshikazu
Park, Kyungho
author_sort Lim, Chae Jin
collection PubMed
description Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
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spelling pubmed-55907952017-09-12 Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis Lim, Chae Jin Lee, Yong-Moon Kang, Seung Goo Lim, Hyung W. Shin, Kyong-Oh Jeong, Se Kyoo Huh, Yang Hoon Choi, Suin Kor, Myungho Seo, Ho Seong Park, Byeong Deog Park, Keedon Ahn, Jeong Keun Uchida, Yoshikazu Park, Kyungho Biomol Ther (Seoul) Original Article Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation. The Korean Society of Applied Pharmacology 2017-09 2017-08-21 /pmc/articles/PMC5590795/ /pubmed/28822991 http://dx.doi.org/10.4062/biomolther.2017.119 Text en Copyright © 2017 The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lim, Chae Jin
Lee, Yong-Moon
Kang, Seung Goo
Lim, Hyung W.
Shin, Kyong-Oh
Jeong, Se Kyoo
Huh, Yang Hoon
Choi, Suin
Kor, Myungho
Seo, Ho Seong
Park, Byeong Deog
Park, Keedon
Ahn, Jeong Keun
Uchida, Yoshikazu
Park, Kyungho
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title_full Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title_fullStr Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title_full_unstemmed Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title_short Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
title_sort aquatide activation of sirt1 reduces cellular senescence through a sirt1-foxo1-autophagy axis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590795/
https://www.ncbi.nlm.nih.gov/pubmed/28822991
http://dx.doi.org/10.4062/biomolther.2017.119
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