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Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?

Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenil...

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Autores principales: Jeong, Ji Seong, Nam, Ki Taek, Lee, Buhyun, Pamungkas, Aryo Dimas, Song, Daeun, Kim, Minjeong, Yu, Wook-Joon, Lee, Jinsoo, Jee, Sunha, Park, Youngja H., Lim, Kyung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590799/
https://www.ncbi.nlm.nih.gov/pubmed/28822992
http://dx.doi.org/10.4062/biomolther.2017.148
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author Jeong, Ji Seong
Nam, Ki Taek
Lee, Buhyun
Pamungkas, Aryo Dimas
Song, Daeun
Kim, Minjeong
Yu, Wook-Joon
Lee, Jinsoo
Jee, Sunha
Park, Youngja H.
Lim, Kyung-Min
author_facet Jeong, Ji Seong
Nam, Ki Taek
Lee, Buhyun
Pamungkas, Aryo Dimas
Song, Daeun
Kim, Minjeong
Yu, Wook-Joon
Lee, Jinsoo
Jee, Sunha
Park, Youngja H.
Lim, Kyung-Min
author_sort Jeong, Ji Seong
collection PubMed
description Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett’s test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C(max), and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C(max) and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.
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spelling pubmed-55907992017-09-14 Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? Jeong, Ji Seong Nam, Ki Taek Lee, Buhyun Pamungkas, Aryo Dimas Song, Daeun Kim, Minjeong Yu, Wook-Joon Lee, Jinsoo Jee, Sunha Park, Youngja H. Lim, Kyung-Min Biomol Ther (Seoul) Original Article Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett’s test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C(max), and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C(max) and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups. The Korean Society of Applied Pharmacology 2017-09 2017-08-21 /pmc/articles/PMC5590799/ /pubmed/28822992 http://dx.doi.org/10.4062/biomolther.2017.148 Text en Copyright © 2017 The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jeong, Ji Seong
Nam, Ki Taek
Lee, Buhyun
Pamungkas, Aryo Dimas
Song, Daeun
Kim, Minjeong
Yu, Wook-Joon
Lee, Jinsoo
Jee, Sunha
Park, Youngja H.
Lim, Kyung-Min
Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title_full Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title_fullStr Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title_full_unstemmed Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title_short Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
title_sort low-dose bisphenol a increases bile duct proliferation in juvenile rats: a possible evidence for risk of liver cancer in the exposed population?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590799/
https://www.ncbi.nlm.nih.gov/pubmed/28822992
http://dx.doi.org/10.4062/biomolther.2017.148
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