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Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?
Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenil...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Applied Pharmacology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590799/ https://www.ncbi.nlm.nih.gov/pubmed/28822992 http://dx.doi.org/10.4062/biomolther.2017.148 |
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author | Jeong, Ji Seong Nam, Ki Taek Lee, Buhyun Pamungkas, Aryo Dimas Song, Daeun Kim, Minjeong Yu, Wook-Joon Lee, Jinsoo Jee, Sunha Park, Youngja H. Lim, Kyung-Min |
author_facet | Jeong, Ji Seong Nam, Ki Taek Lee, Buhyun Pamungkas, Aryo Dimas Song, Daeun Kim, Minjeong Yu, Wook-Joon Lee, Jinsoo Jee, Sunha Park, Youngja H. Lim, Kyung-Min |
author_sort | Jeong, Ji Seong |
collection | PubMed |
description | Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett’s test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C(max), and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C(max) and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups. |
format | Online Article Text |
id | pubmed-5590799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-55907992017-09-14 Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? Jeong, Ji Seong Nam, Ki Taek Lee, Buhyun Pamungkas, Aryo Dimas Song, Daeun Kim, Minjeong Yu, Wook-Joon Lee, Jinsoo Jee, Sunha Park, Youngja H. Lim, Kyung-Min Biomol Ther (Seoul) Original Article Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett’s test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in C(max), and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in C(max) and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups. The Korean Society of Applied Pharmacology 2017-09 2017-08-21 /pmc/articles/PMC5590799/ /pubmed/28822992 http://dx.doi.org/10.4062/biomolther.2017.148 Text en Copyright © 2017 The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jeong, Ji Seong Nam, Ki Taek Lee, Buhyun Pamungkas, Aryo Dimas Song, Daeun Kim, Minjeong Yu, Wook-Joon Lee, Jinsoo Jee, Sunha Park, Youngja H. Lim, Kyung-Min Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title_full | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title_fullStr | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title_full_unstemmed | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title_short | Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population? |
title_sort | low-dose bisphenol a increases bile duct proliferation in juvenile rats: a possible evidence for risk of liver cancer in the exposed population? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590799/ https://www.ncbi.nlm.nih.gov/pubmed/28822992 http://dx.doi.org/10.4062/biomolther.2017.148 |
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