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Systems biology derived source-sink mechanism of BMP gradient formation

A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to generate...

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Detalles Bibliográficos
Autores principales:	Zinski, Joseph, Bu, Ye, Wang, Xu, Dou, Wei, Umulis, David, Mullins, Mary C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590806/ https://www.ncbi.nlm.nih.gov/pubmed/28826472 http://dx.doi.org/10.7554/eLife.22199

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