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Benzene exposure is associated with cardiovascular disease risk

Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk. Despite its prevalence, the cardiovascular effects of benzene have rarely been studied. Hence, we examined whether exposure to benzene is ass...

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Autores principales: Abplanalp, Wesley, DeJarnett, Natasha, Riggs, Daniel W., Conklin, Daniel J., McCracken, James P., Srivastava, Sanjay, Xie, Zhengzhi, Rai, Shesh, Bhatnagar, Aruni, O’Toole, Timothy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590846/
https://www.ncbi.nlm.nih.gov/pubmed/28886060
http://dx.doi.org/10.1371/journal.pone.0183602
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author Abplanalp, Wesley
DeJarnett, Natasha
Riggs, Daniel W.
Conklin, Daniel J.
McCracken, James P.
Srivastava, Sanjay
Xie, Zhengzhi
Rai, Shesh
Bhatnagar, Aruni
O’Toole, Timothy E.
author_facet Abplanalp, Wesley
DeJarnett, Natasha
Riggs, Daniel W.
Conklin, Daniel J.
McCracken, James P.
Srivastava, Sanjay
Xie, Zhengzhi
Rai, Shesh
Bhatnagar, Aruni
O’Toole, Timothy E.
author_sort Abplanalp, Wesley
collection PubMed
description Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk. Despite its prevalence, the cardiovascular effects of benzene have rarely been studied. Hence, we examined whether exposure to benzene is associated with increased CVD risk. The effects of benzene exposure in mice were assessed by direct inhalation, while the effects of benzene exposure in humans was assessed in 210 individuals with mild to high CVD risk by measuring urinary levels of the benzene metabolite trans,trans-muconic acid (t,t-MA). Generalized linear models were used to assess the association between benzene exposure and CVD risk. Mice inhaling volatile benzene had significantly reduced levels of circulating angiogenic cells (Flk-1(+)/Sca-1(+)) as well as an increased levels of plasma low-density lipoprotein (LDL) compared with control mice breathing filtered air. In the human cohort, urinary levels of t,t-MA were inversely associated several populations of circulating angiogenic cells (CD31(+)/34(+)/45(+), CD31(+)/34(+)/45(+)/AC133(–), CD34(+)/45(+)/AC133(+)). Although t,t-MA was not associated with plasma markers of inflammation or thrombosis, t,t-MA levels were higher in smokers and in individuals with dyslipidemia. In smokers, t,t-MA levels were positively associated with urinary metabolites of nicotine (cotinine) and acrolein (3-hydroxymercapturic acid). Levels of t,t-MA were also associated with CVD risk as assessed using the Framingham Risk Score and this association was independent of smoking. Thus, benzene exposure is associated with increased CVD risk and deficits in circulating angiogenic cells in both smokers and non-smokers.
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spelling pubmed-55908462017-09-15 Benzene exposure is associated with cardiovascular disease risk Abplanalp, Wesley DeJarnett, Natasha Riggs, Daniel W. Conklin, Daniel J. McCracken, James P. Srivastava, Sanjay Xie, Zhengzhi Rai, Shesh Bhatnagar, Aruni O’Toole, Timothy E. PLoS One Research Article Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk. Despite its prevalence, the cardiovascular effects of benzene have rarely been studied. Hence, we examined whether exposure to benzene is associated with increased CVD risk. The effects of benzene exposure in mice were assessed by direct inhalation, while the effects of benzene exposure in humans was assessed in 210 individuals with mild to high CVD risk by measuring urinary levels of the benzene metabolite trans,trans-muconic acid (t,t-MA). Generalized linear models were used to assess the association between benzene exposure and CVD risk. Mice inhaling volatile benzene had significantly reduced levels of circulating angiogenic cells (Flk-1(+)/Sca-1(+)) as well as an increased levels of plasma low-density lipoprotein (LDL) compared with control mice breathing filtered air. In the human cohort, urinary levels of t,t-MA were inversely associated several populations of circulating angiogenic cells (CD31(+)/34(+)/45(+), CD31(+)/34(+)/45(+)/AC133(–), CD34(+)/45(+)/AC133(+)). Although t,t-MA was not associated with plasma markers of inflammation or thrombosis, t,t-MA levels were higher in smokers and in individuals with dyslipidemia. In smokers, t,t-MA levels were positively associated with urinary metabolites of nicotine (cotinine) and acrolein (3-hydroxymercapturic acid). Levels of t,t-MA were also associated with CVD risk as assessed using the Framingham Risk Score and this association was independent of smoking. Thus, benzene exposure is associated with increased CVD risk and deficits in circulating angiogenic cells in both smokers and non-smokers. Public Library of Science 2017-09-08 /pmc/articles/PMC5590846/ /pubmed/28886060 http://dx.doi.org/10.1371/journal.pone.0183602 Text en © 2017 Abplanalp et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abplanalp, Wesley
DeJarnett, Natasha
Riggs, Daniel W.
Conklin, Daniel J.
McCracken, James P.
Srivastava, Sanjay
Xie, Zhengzhi
Rai, Shesh
Bhatnagar, Aruni
O’Toole, Timothy E.
Benzene exposure is associated with cardiovascular disease risk
title Benzene exposure is associated with cardiovascular disease risk
title_full Benzene exposure is associated with cardiovascular disease risk
title_fullStr Benzene exposure is associated with cardiovascular disease risk
title_full_unstemmed Benzene exposure is associated with cardiovascular disease risk
title_short Benzene exposure is associated with cardiovascular disease risk
title_sort benzene exposure is associated with cardiovascular disease risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590846/
https://www.ncbi.nlm.nih.gov/pubmed/28886060
http://dx.doi.org/10.1371/journal.pone.0183602
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