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A single-source photon source model of a linear accelerator for Monte Carlo dose calculation

PURPOSE: To introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation. MATERIALS AND METHODS: A PSF of a 6 MV photon beam was generated by simulating the interactions of primary electrons wi...

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Autores principales: Nwankwo, Obioma, Glatting, Gerhard, Wenz, Frederik, Fleckenstein, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590861/
https://www.ncbi.nlm.nih.gov/pubmed/28886048
http://dx.doi.org/10.1371/journal.pone.0183486
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author Nwankwo, Obioma
Glatting, Gerhard
Wenz, Frederik
Fleckenstein, Jens
author_facet Nwankwo, Obioma
Glatting, Gerhard
Wenz, Frederik
Fleckenstein, Jens
author_sort Nwankwo, Obioma
collection PubMed
description PURPOSE: To introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation. MATERIALS AND METHODS: A PSF of a 6 MV photon beam was generated by simulating the interactions of primary electrons with the relevant geometries of a Synergy linear accelerator (Elekta AB, Stockholm, Sweden) and recording the particles that reach a plane 16 cm downstream the electron source. Probability distribution functions (PDFs) for particle positions and energies were derived from the analysis of the PSF. These PDFs were implemented in the VSM using inverse transform sampling. To model particle directions, the phase space plane was divided into a regular square grid. Each element of the grid corresponds to an area of 1 mm(2) in the phase space plane. The average direction cosines, Pearson correlation coefficient (PCC) between photon energies and their direction cosines, as well as the PCC between the direction cosines were calculated for each grid element. Weighted polynomial surfaces were then fitted to these 2D data. The weights are used to correct for heteroscedasticity across the phase space bins. The directions of the particles created by the VSM were calculated from these fitted functions. The VSM was validated against the PSF by comparing the doses calculated by the two methods for different square field sizes. The comparisons were performed with profile and gamma analyses. RESULTS: The doses calculated with the PSF and VSM agree to within 3% /1 mm (>95% pixel pass rate) for the evaluated fields. CONCLUSION: A new method of deriving a virtual photon source model of a linear accelerator from a PSF file for MC dose calculation was developed. Validation results show that the doses calculated with the VSM and the PSF agree to within 3% /1 mm.
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spelling pubmed-55908612017-09-15 A single-source photon source model of a linear accelerator for Monte Carlo dose calculation Nwankwo, Obioma Glatting, Gerhard Wenz, Frederik Fleckenstein, Jens PLoS One Research Article PURPOSE: To introduce a new method of deriving a virtual source model (VSM) of a linear accelerator photon beam from a phase space file (PSF) for Monte Carlo (MC) dose calculation. MATERIALS AND METHODS: A PSF of a 6 MV photon beam was generated by simulating the interactions of primary electrons with the relevant geometries of a Synergy linear accelerator (Elekta AB, Stockholm, Sweden) and recording the particles that reach a plane 16 cm downstream the electron source. Probability distribution functions (PDFs) for particle positions and energies were derived from the analysis of the PSF. These PDFs were implemented in the VSM using inverse transform sampling. To model particle directions, the phase space plane was divided into a regular square grid. Each element of the grid corresponds to an area of 1 mm(2) in the phase space plane. The average direction cosines, Pearson correlation coefficient (PCC) between photon energies and their direction cosines, as well as the PCC between the direction cosines were calculated for each grid element. Weighted polynomial surfaces were then fitted to these 2D data. The weights are used to correct for heteroscedasticity across the phase space bins. The directions of the particles created by the VSM were calculated from these fitted functions. The VSM was validated against the PSF by comparing the doses calculated by the two methods for different square field sizes. The comparisons were performed with profile and gamma analyses. RESULTS: The doses calculated with the PSF and VSM agree to within 3% /1 mm (>95% pixel pass rate) for the evaluated fields. CONCLUSION: A new method of deriving a virtual photon source model of a linear accelerator from a PSF file for MC dose calculation was developed. Validation results show that the doses calculated with the VSM and the PSF agree to within 3% /1 mm. Public Library of Science 2017-09-08 /pmc/articles/PMC5590861/ /pubmed/28886048 http://dx.doi.org/10.1371/journal.pone.0183486 Text en © 2017 Nwankwo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nwankwo, Obioma
Glatting, Gerhard
Wenz, Frederik
Fleckenstein, Jens
A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title_full A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title_fullStr A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title_full_unstemmed A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title_short A single-source photon source model of a linear accelerator for Monte Carlo dose calculation
title_sort single-source photon source model of a linear accelerator for monte carlo dose calculation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590861/
https://www.ncbi.nlm.nih.gov/pubmed/28886048
http://dx.doi.org/10.1371/journal.pone.0183486
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