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Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis

OBJECTIVE: The purpose of this study was to systematically determine the effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes. METHODS: Electronic databases including MEDLINE, CENTRAL, CINAHL, Scopus, ScienceDirect(®), Proquest, Web of Science(®), LILACS, NAPRALERT, SciFinde...

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Detalles Bibliográficos
Autores principales: Poolsup, Nalinee, Suksomboon, Naeti, Paw, Naw Juna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590977/
https://www.ncbi.nlm.nih.gov/pubmed/28886195
http://dx.doi.org/10.1371/journal.pone.0184577
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author Poolsup, Nalinee
Suksomboon, Naeti
Paw, Naw Juna
author_facet Poolsup, Nalinee
Suksomboon, Naeti
Paw, Naw Juna
author_sort Poolsup, Nalinee
collection PubMed
description OBJECTIVE: The purpose of this study was to systematically determine the effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes. METHODS: Electronic databases including MEDLINE, CENTRAL, CINAHL, Scopus, ScienceDirect(®), Proquest, Web of Science(®), LILACS, NAPRALERT, SciFinder, Clinicalkey, Herbmed, NCCIH and Google Scholar were searched from their earliest inception up to March 2017 for relevant randomized controlled trials (RCTs) which compared dragon fruit with placebo or no treatment in prediabetes or type 2 diabetes. Clinicaltrials.gov, clinicaltrialresults.org, and ISRCTN registry were also searched. Personal contact with experts and historical search of related articles was undertaken. Outcome of interest were fasting plasma glucose (FPG) and 2 hours post-prandial glucose (2HPP). Study selection, data extraction and study quality assessment were performed independently by two investigators. Disagreements were resolved by a third reviewer. Treatment effect was estimated with mean difference (MD). Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed with the Q statistic and quantified with the I(2) statistic. DerSimonian and Laird random-effects model was used when the Q-statistic was significant at the level of 0.1, otherwise a fixed-effects model was used. RESULTS: Among 401 studies identified from literature search, 4 RCTs involving 36 prediabetes subjects and 109 type 2 diabetes patients were included in the analysis. In prediabetes, FPG reduction was significant with MD of -15.1 mg/dL (95% CI: -23.8 to -6.5 mg/dL, P-value = 0.0006). Meta-analysis in type 2 diabetes showed no effect of dragon fruit on FPG (MD -26.5 mg/dL, 95% CI: -72.6 mg/dL to 19.6 mg/dL) and in 2HPP (MD -30.5 mg/dL, 95% CI: -80.9 mg/dL to 19.9 mg/dL). CONCLUSION: The available evidence in prediabetes is interesting. This will shed some light on diabetes prevention. The effect in T2DM was not significant. However, a trend towards greater blood glucose reduction with higher dose was observed.
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spelling pubmed-55909772017-09-15 Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis Poolsup, Nalinee Suksomboon, Naeti Paw, Naw Juna PLoS One Research Article OBJECTIVE: The purpose of this study was to systematically determine the effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes. METHODS: Electronic databases including MEDLINE, CENTRAL, CINAHL, Scopus, ScienceDirect(®), Proquest, Web of Science(®), LILACS, NAPRALERT, SciFinder, Clinicalkey, Herbmed, NCCIH and Google Scholar were searched from their earliest inception up to March 2017 for relevant randomized controlled trials (RCTs) which compared dragon fruit with placebo or no treatment in prediabetes or type 2 diabetes. Clinicaltrials.gov, clinicaltrialresults.org, and ISRCTN registry were also searched. Personal contact with experts and historical search of related articles was undertaken. Outcome of interest were fasting plasma glucose (FPG) and 2 hours post-prandial glucose (2HPP). Study selection, data extraction and study quality assessment were performed independently by two investigators. Disagreements were resolved by a third reviewer. Treatment effect was estimated with mean difference (MD). Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed with the Q statistic and quantified with the I(2) statistic. DerSimonian and Laird random-effects model was used when the Q-statistic was significant at the level of 0.1, otherwise a fixed-effects model was used. RESULTS: Among 401 studies identified from literature search, 4 RCTs involving 36 prediabetes subjects and 109 type 2 diabetes patients were included in the analysis. In prediabetes, FPG reduction was significant with MD of -15.1 mg/dL (95% CI: -23.8 to -6.5 mg/dL, P-value = 0.0006). Meta-analysis in type 2 diabetes showed no effect of dragon fruit on FPG (MD -26.5 mg/dL, 95% CI: -72.6 mg/dL to 19.6 mg/dL) and in 2HPP (MD -30.5 mg/dL, 95% CI: -80.9 mg/dL to 19.9 mg/dL). CONCLUSION: The available evidence in prediabetes is interesting. This will shed some light on diabetes prevention. The effect in T2DM was not significant. However, a trend towards greater blood glucose reduction with higher dose was observed. Public Library of Science 2017-09-08 /pmc/articles/PMC5590977/ /pubmed/28886195 http://dx.doi.org/10.1371/journal.pone.0184577 Text en © 2017 Poolsup et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Poolsup, Nalinee
Suksomboon, Naeti
Paw, Naw Juna
Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title_full Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title_fullStr Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title_full_unstemmed Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title_short Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis
title_sort effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590977/
https://www.ncbi.nlm.nih.gov/pubmed/28886195
http://dx.doi.org/10.1371/journal.pone.0184577
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