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Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model
In this study, we present a fully-coupled fluid-structure interaction (FSI) framework that combines smoothed particle hydrodynamics (SPH) and nonlinear finite element (FE) method to investigate the coupled aortic and mitral valves structural response and the bulk intraventricular hemodynamics in a r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590990/ https://www.ncbi.nlm.nih.gov/pubmed/28886196 http://dx.doi.org/10.1371/journal.pone.0184729 |
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author | Mao, Wenbin Caballero, Andrés McKay, Raymond Primiano, Charles Sun, Wei |
author_facet | Mao, Wenbin Caballero, Andrés McKay, Raymond Primiano, Charles Sun, Wei |
author_sort | Mao, Wenbin |
collection | PubMed |
description | In this study, we present a fully-coupled fluid-structure interaction (FSI) framework that combines smoothed particle hydrodynamics (SPH) and nonlinear finite element (FE) method to investigate the coupled aortic and mitral valves structural response and the bulk intraventricular hemodynamics in a realistic left ventricle (LV) model during the entire cardiac cycle. The FSI model incorporates valve structures that consider native asymmetric leaflet geometries, anisotropic hyperelastic material models and human material properties. Comparison of FSI results with subject-specific echocardiography data demonstrates that the SPH-FE approach is able to quantitatively predict the opening and closing times of the valves, the mitral leaflet opening and closing angles, and the large-scale intraventricular flow phenomena with a reasonable agreement. Moreover, comparison of FSI results with a LV model without valves reveals substantial differences in the flow field. Peak systolic velocities obtained from the FSI model and the LV model without valves are 2.56 m/s and 1.16 m/s, respectively, compared to the Doppler echo data of 2.17 m/s. The proposed SPH-FE FSI framework represents a further step towards modeling patient-specific coupled LV-valve dynamics, and has the potential to improve our understanding of cardiovascular physiology and to support professionals in clinical decision-making. |
format | Online Article Text |
id | pubmed-5590990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55909902017-09-15 Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model Mao, Wenbin Caballero, Andrés McKay, Raymond Primiano, Charles Sun, Wei PLoS One Research Article In this study, we present a fully-coupled fluid-structure interaction (FSI) framework that combines smoothed particle hydrodynamics (SPH) and nonlinear finite element (FE) method to investigate the coupled aortic and mitral valves structural response and the bulk intraventricular hemodynamics in a realistic left ventricle (LV) model during the entire cardiac cycle. The FSI model incorporates valve structures that consider native asymmetric leaflet geometries, anisotropic hyperelastic material models and human material properties. Comparison of FSI results with subject-specific echocardiography data demonstrates that the SPH-FE approach is able to quantitatively predict the opening and closing times of the valves, the mitral leaflet opening and closing angles, and the large-scale intraventricular flow phenomena with a reasonable agreement. Moreover, comparison of FSI results with a LV model without valves reveals substantial differences in the flow field. Peak systolic velocities obtained from the FSI model and the LV model without valves are 2.56 m/s and 1.16 m/s, respectively, compared to the Doppler echo data of 2.17 m/s. The proposed SPH-FE FSI framework represents a further step towards modeling patient-specific coupled LV-valve dynamics, and has the potential to improve our understanding of cardiovascular physiology and to support professionals in clinical decision-making. Public Library of Science 2017-09-08 /pmc/articles/PMC5590990/ /pubmed/28886196 http://dx.doi.org/10.1371/journal.pone.0184729 Text en © 2017 Mao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mao, Wenbin Caballero, Andrés McKay, Raymond Primiano, Charles Sun, Wei Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title | Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title_full | Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title_fullStr | Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title_full_unstemmed | Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title_short | Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model |
title_sort | fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3d left ventricle model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590990/ https://www.ncbi.nlm.nih.gov/pubmed/28886196 http://dx.doi.org/10.1371/journal.pone.0184729 |
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