HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes

The major histocompatibility complex (MHC) contains the most polymorphic genetic system in humans, the human leukocyte antigen (HLA) genes of the adaptive immune system. High allelic diversity in HLA is argued to be maintained by balancing selection, such as negative frequency-dependent selection or...

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Detalles Bibliográficos
Autores principales: Alter, Idan, Gragert, Loren, Fingerson, Stephanie, Maiers, Martin, Louzoun, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590998/
https://www.ncbi.nlm.nih.gov/pubmed/28846675
http://dx.doi.org/10.1371/journal.pcbi.1005693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590998/
https://www.ncbi.nlm.nih.gov/pubmed/28846675
http://dx.doi.org/10.1371/journal.pcbi.1005693

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