HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells

HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell clones. Here, we show that in 30/87 (34%) patient...

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Detalles Bibliográficos
Autores principales: Cesana, Daniela, Santoni de Sio, Francesca R., Rudilosso, Laura, Gallina, Pierangela, Calabria, Andrea, Beretta, Stefano, Merelli, Ivan, Bruzzesi, Elena, Passerini, Laura, Nozza, Silvia, Vicenzi, Elisa, Poli, Guido, Gregori, Silvia, Tambussi, Giuseppe, Montini, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591266/
https://www.ncbi.nlm.nih.gov/pubmed/28887441
http://dx.doi.org/10.1038/s41467-017-00609-1

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