Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells

Concomitant expressions of glycan-binding proteins and their bound glycans regulate many pathophysiologic processes, but this issue has not been addressed in liver fibrosis. Activation of hepatic stellate cells (HSCs) is a rate-limiting step in liver fibrosis and is an important target for liver fib...

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Detalles Bibliográficos
Autores principales: Wu, Ming-Heng, Chen, Yuh-Ling, Lee, Kuen-Haur, Chang, Che-Chang, Cheng, Tsai-Mu, Wu, Szu-Yuan, Tu, Chao-Chiang, Tsui, Wan-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591297/
https://www.ncbi.nlm.nih.gov/pubmed/28887481
http://dx.doi.org/10.1038/s41598-017-11212-1

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