CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained. We have previously shown that WHIM-mutant T cells form unstable immunological synapse...

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Detalles Bibliográficos
Autores principales: Roselli, Giuliana, Martini, Elisa, Lougaris, Vassilios, Badolato, Raffaele, Viola, Antonella, Kallikourdis, Marinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591327/
https://www.ncbi.nlm.nih.gov/pubmed/28928741
http://dx.doi.org/10.3389/fimmu.2017.01068

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