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Lipid levels and risk of venous thrombosis: results from the MEGA-study

The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case–control study, and to evaluate the underlying mechanism, considering confoundin...

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Autores principales: Morelli, Vânia M., Lijfering, Willem M., Bos, Mettine H. A., Rosendaal, Frits R., Cannegieter, Suzanne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591362/
https://www.ncbi.nlm.nih.gov/pubmed/28540474
http://dx.doi.org/10.1007/s10654-017-0251-1
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author Morelli, Vânia M.
Lijfering, Willem M.
Bos, Mettine H. A.
Rosendaal, Frits R.
Cannegieter, Suzanne C.
author_facet Morelli, Vânia M.
Lijfering, Willem M.
Bos, Mettine H. A.
Rosendaal, Frits R.
Cannegieter, Suzanne C.
author_sort Morelli, Vânia M.
collection PubMed
description The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case–control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive protein. From the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA) study, 2234 patients with a first venous thrombosis and 2873 controls were included. Percentile categories of total/low-density lipoprotein/high-density lipoprotein cholesterol, triglycerides, and apolipoproteins B and A1 were established in controls (<10th, 10th–25th, 25th–75th [reference], 75th–90th, >90th percentile). In age- and sex-adjusted models, decreasing levels of apolipoproteins B and A1 were dose-dependently associated with increased thrombosis risk, with odds ratios of 1.35 (95% confidence interval 1.12–1.62) and 1.50 (95% confidence interval 1.25–1.79) for the lowest category versus the reference category, respectively. The dose–response relation remained with further adjustment for body mass index, estrogen use, statin use, and diabetes. Although apolipoproteins B and A1 were associated with several hemostatic factors and C-reactive protein, none explained the increased risk in mediation analyses. The other lipids were not associated with venous thrombosis risk. In conclusion, decreasing levels of apolipoproteins B and A1 were associated with increased risk of venous thrombosis. Our findings are consistent with experimental data on the anticoagulant properties of apolipoproteins B and A1. These findings need to be confirmed and the underlying mechanism further investigated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10654-017-0251-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-55913622017-09-25 Lipid levels and risk of venous thrombosis: results from the MEGA-study Morelli, Vânia M. Lijfering, Willem M. Bos, Mettine H. A. Rosendaal, Frits R. Cannegieter, Suzanne C. Eur J Epidemiol Cardiovascular Disease The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case–control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive protein. From the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA) study, 2234 patients with a first venous thrombosis and 2873 controls were included. Percentile categories of total/low-density lipoprotein/high-density lipoprotein cholesterol, triglycerides, and apolipoproteins B and A1 were established in controls (<10th, 10th–25th, 25th–75th [reference], 75th–90th, >90th percentile). In age- and sex-adjusted models, decreasing levels of apolipoproteins B and A1 were dose-dependently associated with increased thrombosis risk, with odds ratios of 1.35 (95% confidence interval 1.12–1.62) and 1.50 (95% confidence interval 1.25–1.79) for the lowest category versus the reference category, respectively. The dose–response relation remained with further adjustment for body mass index, estrogen use, statin use, and diabetes. Although apolipoproteins B and A1 were associated with several hemostatic factors and C-reactive protein, none explained the increased risk in mediation analyses. The other lipids were not associated with venous thrombosis risk. In conclusion, decreasing levels of apolipoproteins B and A1 were associated with increased risk of venous thrombosis. Our findings are consistent with experimental data on the anticoagulant properties of apolipoproteins B and A1. These findings need to be confirmed and the underlying mechanism further investigated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10654-017-0251-1) contains supplementary material, which is available to authorized users. Springer Netherlands 2017-05-24 2017 /pmc/articles/PMC5591362/ /pubmed/28540474 http://dx.doi.org/10.1007/s10654-017-0251-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Cardiovascular Disease
Morelli, Vânia M.
Lijfering, Willem M.
Bos, Mettine H. A.
Rosendaal, Frits R.
Cannegieter, Suzanne C.
Lipid levels and risk of venous thrombosis: results from the MEGA-study
title Lipid levels and risk of venous thrombosis: results from the MEGA-study
title_full Lipid levels and risk of venous thrombosis: results from the MEGA-study
title_fullStr Lipid levels and risk of venous thrombosis: results from the MEGA-study
title_full_unstemmed Lipid levels and risk of venous thrombosis: results from the MEGA-study
title_short Lipid levels and risk of venous thrombosis: results from the MEGA-study
title_sort lipid levels and risk of venous thrombosis: results from the mega-study
topic Cardiovascular Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591362/
https://www.ncbi.nlm.nih.gov/pubmed/28540474
http://dx.doi.org/10.1007/s10654-017-0251-1
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