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Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

The identification of mutations that enhance antibody affinity while maintaining high antibody specificity and stability is a time-consuming and laborious process. Here, we report an efficient methodology for systematically and rapidly enhancing the affinity of antibody variable domains while maximi...

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Detalles Bibliográficos
Autores principales:	Tiller, Kathryn E., Chowdhury, Ratul, Li, Tong, Ludwig, Seth D., Sen, Sabyasachi, Maranas, Costas D., Tessier, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591402/ https://www.ncbi.nlm.nih.gov/pubmed/28928732 http://dx.doi.org/10.3389/fimmu.2017.00986

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