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Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

BACKGROUND: Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhibitors (olapar...

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Detalles Bibliográficos
Autores principales:	Philip, Charles-André, Laskov, Ido, Beauchamp, Marie-Claude, Marques, Maud, Amin, Oreekha, Bitharas, Joanna, Kessous, Roy, Kogan, Liron, Baloch, Tahira, Gotlieb, Walter H., Yasmeen, Amber
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591502/ https://www.ncbi.nlm.nih.gov/pubmed/28886696 http://dx.doi.org/10.1186/s12885-017-3639-0

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