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Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats

BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats. METHODS: R...

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Autores principales: Zhu, Wenhua, Chen, Siwen, Chen, Ronggui, Peng, Zhiqing, Wan, Jun, Wu, Benyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591522/
https://www.ncbi.nlm.nih.gov/pubmed/28886741
http://dx.doi.org/10.1186/s12906-017-1961-3
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author Zhu, Wenhua
Chen, Siwen
Chen, Ronggui
Peng, Zhiqing
Wan, Jun
Wu, Benyan
author_facet Zhu, Wenhua
Chen, Siwen
Chen, Ronggui
Peng, Zhiqing
Wan, Jun
Wu, Benyan
author_sort Zhu, Wenhua
collection PubMed
description BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats. METHODS: Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (including taurine, TPs, or taurine + TPs treatment for 8 weeks). Twelve weeks later, all rats were sacrificed, and serum transaminase, lipid and lipopolysaccharide levels and hepatic oxidative stress levels were determined. Histological changes were evaluated. RESULTS: In NASH rats, hepatocyte damage, lipid disturbance, oxidative stress and elevated lipopolysaccharide levels were confirmed. Taurine treatment alleviated hepatocyte damage and oxidative stress. TPs treatment improved lipid metabolism and increased hepatic antioxidant activity. The therapeutic effects of taurine + TPs treatment on hepatocyte damage, lipid disturbance, and oxidative stress were superior to those of taurine and TPs treatment, respectively. Taurine, TPs and their combination all decreased serum lipopolysaccharide levels in NASH rats, but the combination of the compounds caused these levels to decrease more significantly than taurine or TPs treatment alone. CONCLUSION: Taurine combined with TPs treatment could relieve NASH by alleviating hepatocyte damage, decreasing oxidative stress and improving lipid metabolism and gut flora disturbance partly. Taurine and TPs combination may act as a new effective medicine for treating NASH patients.
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spelling pubmed-55915222017-09-13 Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats Zhu, Wenhua Chen, Siwen Chen, Ronggui Peng, Zhiqing Wan, Jun Wu, Benyan BMC Complement Altern Med Research Article BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats. METHODS: Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (including taurine, TPs, or taurine + TPs treatment for 8 weeks). Twelve weeks later, all rats were sacrificed, and serum transaminase, lipid and lipopolysaccharide levels and hepatic oxidative stress levels were determined. Histological changes were evaluated. RESULTS: In NASH rats, hepatocyte damage, lipid disturbance, oxidative stress and elevated lipopolysaccharide levels were confirmed. Taurine treatment alleviated hepatocyte damage and oxidative stress. TPs treatment improved lipid metabolism and increased hepatic antioxidant activity. The therapeutic effects of taurine + TPs treatment on hepatocyte damage, lipid disturbance, and oxidative stress were superior to those of taurine and TPs treatment, respectively. Taurine, TPs and their combination all decreased serum lipopolysaccharide levels in NASH rats, but the combination of the compounds caused these levels to decrease more significantly than taurine or TPs treatment alone. CONCLUSION: Taurine combined with TPs treatment could relieve NASH by alleviating hepatocyte damage, decreasing oxidative stress and improving lipid metabolism and gut flora disturbance partly. Taurine and TPs combination may act as a new effective medicine for treating NASH patients. BioMed Central 2017-09-08 /pmc/articles/PMC5591522/ /pubmed/28886741 http://dx.doi.org/10.1186/s12906-017-1961-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhu, Wenhua
Chen, Siwen
Chen, Ronggui
Peng, Zhiqing
Wan, Jun
Wu, Benyan
Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title_full Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title_fullStr Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title_full_unstemmed Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title_short Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
title_sort taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591522/
https://www.ncbi.nlm.nih.gov/pubmed/28886741
http://dx.doi.org/10.1186/s12906-017-1961-3
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