Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation

In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and...

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Detalles Bibliográficos
Autores principales: Fassina, Lorenzo, Cornacchione, Marisa, Pellegrini, Manuela, Mognaschi, Maria Evelina, Gimmelli, Roberto, Isidori, Andrea Maria, Lenzi, Andrea, Magenes, Giovanni, Naro, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591919/
https://www.ncbi.nlm.nih.gov/pubmed/29065600
http://dx.doi.org/10.1155/2017/4204085
Descripción
Sumario:In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.

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