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Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation
In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591919/ https://www.ncbi.nlm.nih.gov/pubmed/29065600 http://dx.doi.org/10.1155/2017/4204085 |
| _version_ | 1783262810529071104 |
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| author | Fassina, Lorenzo Cornacchione, Marisa Pellegrini, Manuela Mognaschi, Maria Evelina Gimmelli, Roberto Isidori, Andrea Maria Lenzi, Andrea Magenes, Giovanni Naro, Fabio |
| author_facet | Fassina, Lorenzo Cornacchione, Marisa Pellegrini, Manuela Mognaschi, Maria Evelina Gimmelli, Roberto Isidori, Andrea Maria Lenzi, Andrea Magenes, Giovanni Naro, Fabio |
| author_sort | Fassina, Lorenzo |
| collection | PubMed |
| description | In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response. |
| format | Online Article Text |
| id | pubmed-5591919 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Hindawi |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55919192017-09-20 Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation Fassina, Lorenzo Cornacchione, Marisa Pellegrini, Manuela Mognaschi, Maria Evelina Gimmelli, Roberto Isidori, Andrea Maria Lenzi, Andrea Magenes, Giovanni Naro, Fabio J Healthc Eng Research Article In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response. Hindawi 2017 2017-08-08 /pmc/articles/PMC5591919/ /pubmed/29065600 http://dx.doi.org/10.1155/2017/4204085 Text en Copyright © 2017 Lorenzo Fassina et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Fassina, Lorenzo Cornacchione, Marisa Pellegrini, Manuela Mognaschi, Maria Evelina Gimmelli, Roberto Isidori, Andrea Maria Lenzi, Andrea Magenes, Giovanni Naro, Fabio Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title | Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title_full | Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title_fullStr | Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title_full_unstemmed | Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title_short | Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation |
| title_sort | model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and β-adrenergic stimulation |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591919/ https://www.ncbi.nlm.nih.gov/pubmed/29065600 http://dx.doi.org/10.1155/2017/4204085 |
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