Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM

Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication...

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Detalles Bibliográficos
Autores principales: Ahmed, Marwan A., Muntingh, George L., Rheeder, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591993/
https://www.ncbi.nlm.nih.gov/pubmed/28932240
http://dx.doi.org/10.1155/2017/2452853
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author Ahmed, Marwan A.
Muntingh, George L.
Rheeder, Paul
author_facet Ahmed, Marwan A.
Muntingh, George L.
Rheeder, Paul
author_sort Ahmed, Marwan A.
collection PubMed
description Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.
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spelling pubmed-55919932017-09-20 Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM Ahmed, Marwan A. Muntingh, George L. Rheeder, Paul Int J Endocrinol Review Article Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies. Hindawi 2017 2017-08-27 /pmc/articles/PMC5591993/ /pubmed/28932240 http://dx.doi.org/10.1155/2017/2452853 Text en Copyright © 2017 Marwan A. Ahmed et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmed, Marwan A.
Muntingh, George L.
Rheeder, Paul
Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title_full Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title_fullStr Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title_full_unstemmed Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title_short Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM
title_sort perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin b12 deficiency in t2dm
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591993/
https://www.ncbi.nlm.nih.gov/pubmed/28932240
http://dx.doi.org/10.1155/2017/2452853
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AT rheederpaul perspectivesonperipheralneuropathyasaconsequenceofmetformininducedvitaminb12deficiencyint2dm

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