Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors

It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified recurrent but divergent missense mutations in the substrate recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate canc...

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Detalles Bibliográficos
Autores principales: Janouskova, Hana, Tekle, Geniver El, Bellini, Elisa, Udeshi, Namrata D., Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M., Kryukov, Gregory V., Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I., Mutch, David G., Carney, Michael E., Berchuck, Andrew, Winterhoff, Boris J.N., Broaddus, Russell R., Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V., Peter, Matthias, Carr, Steven A., Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592092/
https://www.ncbi.nlm.nih.gov/pubmed/28805821
http://dx.doi.org/10.1038/nm.4372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592092/
https://www.ncbi.nlm.nih.gov/pubmed/28805821
http://dx.doi.org/10.1038/nm.4372

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