Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea

Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA(®) XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs)...

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Autores principales: Kim, Min Chul, Kim, Yong Sook, Kang, Wan Seok, Lee, Ki Hong, Cho, Meeyoung, Hong, Moon Hwa, Lim, Kyung Seob, Jeong, Myung Ho, Ahn, Youngkeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592188/
https://www.ncbi.nlm.nih.gov/pubmed/28875618
http://dx.doi.org/10.3346/jkms.2017.32.10.1708
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author Kim, Min Chul
Kim, Yong Sook
Kang, Wan Seok
Lee, Ki Hong
Cho, Meeyoung
Hong, Moon Hwa
Lim, Kyung Seob
Jeong, Myung Ho
Ahn, Youngkeun
author_facet Kim, Min Chul
Kim, Yong Sook
Kang, Wan Seok
Lee, Ki Hong
Cho, Meeyoung
Hong, Moon Hwa
Lim, Kyung Seob
Jeong, Myung Ho
Ahn, Youngkeun
author_sort Kim, Min Chul
collection PubMed
description Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA(®) XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
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spelling pubmed-55921882017-10-01 Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea Kim, Min Chul Kim, Yong Sook Kang, Wan Seok Lee, Ki Hong Cho, Meeyoung Hong, Moon Hwa Lim, Kyung Seob Jeong, Myung Ho Ahn, Youngkeun J Korean Med Sci Brief Communication Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA(®) XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future. The Korean Academy of Medical Sciences 2017-10 2017-08-10 /pmc/articles/PMC5592188/ /pubmed/28875618 http://dx.doi.org/10.3346/jkms.2017.32.10.1708 Text en © 2017 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Kim, Min Chul
Kim, Yong Sook
Kang, Wan Seok
Lee, Ki Hong
Cho, Meeyoung
Hong, Moon Hwa
Lim, Kyung Seob
Jeong, Myung Ho
Ahn, Youngkeun
Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title_full Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title_fullStr Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title_full_unstemmed Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title_short Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
title_sort intramyocardial injection of stem cells in pig myocardial infarction model: the first trial in korea
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592188/
https://www.ncbi.nlm.nih.gov/pubmed/28875618
http://dx.doi.org/10.3346/jkms.2017.32.10.1708
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