Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis

PURPOSE: The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis. MATERIALS AND METHODS: 5...

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Autores principales: Salomon, Joanna, Matusiak, Łukasz, Nowicka-Suszko, Danuta, Szepietowski, Jacek C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592393/
https://www.ncbi.nlm.nih.gov/pubmed/28932021
http://dx.doi.org/10.1155/2017/9538451
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author Salomon, Joanna
Matusiak, Łukasz
Nowicka-Suszko, Danuta
Szepietowski, Jacek C.
author_facet Salomon, Joanna
Matusiak, Łukasz
Nowicka-Suszko, Danuta
Szepietowski, Jacek C.
author_sort Salomon, Joanna
collection PubMed
description PURPOSE: The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis. MATERIALS AND METHODS: 55 psoriatic patients were enrolled, including 21 men and 34 women, aged from 18 to 88 years. The PASI and body surface area were calculated for all patients. Blood samples were taken to evaluate serum concentration of YKL-40, as well as other inflammatory parameters, including CRP, ESR, white blood cell count, and neutrophil count. The measurements of YKL-40 level were performed by enzyme-linked immunosorbent assay (ELISA). RESULTS: YKL-40 serum concentration was significantly higher in psoriatic patients than in the control group. No correlations were found between YKL-40 levels and other clinical or laboratory parameters. Serum YKL-40 level was elevated in 81.8% patients, whereas CRP and WBC in 20% and 7.3% of patients, respectively. CONCLUSIONS: YKL-40 could be considered as a useful biomarker of inflammation in psoriasis and is more sensitive than CRP or WBC. Increased YKL-40 may indicate psoriatic patients with a higher level of systemic inflammation, which may determine disease management.
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spelling pubmed-55923932017-09-20 Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis Salomon, Joanna Matusiak, Łukasz Nowicka-Suszko, Danuta Szepietowski, Jacek C. Mediators Inflamm Research Article PURPOSE: The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis. MATERIALS AND METHODS: 55 psoriatic patients were enrolled, including 21 men and 34 women, aged from 18 to 88 years. The PASI and body surface area were calculated for all patients. Blood samples were taken to evaluate serum concentration of YKL-40, as well as other inflammatory parameters, including CRP, ESR, white blood cell count, and neutrophil count. The measurements of YKL-40 level were performed by enzyme-linked immunosorbent assay (ELISA). RESULTS: YKL-40 serum concentration was significantly higher in psoriatic patients than in the control group. No correlations were found between YKL-40 levels and other clinical or laboratory parameters. Serum YKL-40 level was elevated in 81.8% patients, whereas CRP and WBC in 20% and 7.3% of patients, respectively. CONCLUSIONS: YKL-40 could be considered as a useful biomarker of inflammation in psoriasis and is more sensitive than CRP or WBC. Increased YKL-40 may indicate psoriatic patients with a higher level of systemic inflammation, which may determine disease management. Hindawi 2017 2017-08-28 /pmc/articles/PMC5592393/ /pubmed/28932021 http://dx.doi.org/10.1155/2017/9538451 Text en Copyright © 2017 Joanna Salomon et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salomon, Joanna
Matusiak, Łukasz
Nowicka-Suszko, Danuta
Szepietowski, Jacek C.
Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title_full Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title_fullStr Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title_full_unstemmed Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title_short Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis
title_sort chitinase-3-like protein 1 (ykl-40) is a new biomarker of inflammation in psoriasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592393/
https://www.ncbi.nlm.nih.gov/pubmed/28932021
http://dx.doi.org/10.1155/2017/9538451
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