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LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

Leucine-rich repeat-containing G protein–coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most notably in the intestinal crypts, and is highly up-regulated in many colorectal, hepatocellular, and ovarian cancers. LGR5 activation by R-spondin (RSPO) l...

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Detalles Bibliográficos
Autores principales:	Carmon, Kendra S., Gong, Xing, Yi, Jing, Wu, Ling, Thomas, Anthony, Moore, Catherine M., Masuho, Ikuo, Timson, David J., Martemyanov, Kirill A., Liu, Qingyun J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592675/ https://www.ncbi.nlm.nih.gov/pubmed/28739799 http://dx.doi.org/10.1074/jbc.M117.786798

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