Remission of type 2 diabetes in a hypogonadal man under long-term testosterone therapy

In daily practice, clinicians are often confronted with obese type 2 diabetes mellitus (T2DM) patients for whom the treatment plan fails and who show an inadequate glycemic control and/or no sustainable weight loss. Untreated hypogonadism can be the reason for such treatment failure. This case describes the profound impact testosterone therapy can have on a male hypogonadal patient with metabolic syndrome, resulting in a substantial and sustained loss of body weight, pronounced improvement of all critical laboratory values and finally complete remission of diabetes. LEARNING POINTS: Hypogonadism occurs frequently in men with T2DM. In case of pronounced abdominal fat deposition and T2DM, the male patient should be evaluated for testosterone deficiency. Untreated hypogonadism can complicate the successful treatment of patients with T2DM. Under testosterone therapy, critical laboratory values are facilitated to return back to normal ranges and even complete remission of diabetes can be achieved.