Cooperative oncogenic effect and cell signaling crosstalk of co-occurring HER2 and mutant PIK3CA in mammary epithelial cells

Though incidence of PI3K oncogenic mutation is prominent in breast cancer (20-30%), pharmacological targeting of this signaling pathway alone has failed to provide meaningful clinical benefit. To better understand and address this problem, we conducted genome-wide analysis to study the association o...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Lun, Meng, Fanyan, Wu, Ling, Mitchell, Allison V., Block, C. James, Zhang, Bin, Craig, Douglas B., Jang, Hyejeong, Chen, Wei, Yang, Qifeng, Wu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592866/
https://www.ncbi.nlm.nih.gov/pubmed/28902361
http://dx.doi.org/10.3892/ijo.2017.4108

Ejemplares similares

Ejemplares similares