Cargando…

Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer

Cancers acquire multiple somatic mutations that can lead to the generation of immunogenic mutation-induced neoantigens. These neoantigens can be recognized by the host's immune system. However, continuous stimulation of immune cells against tumor antigens can lead to immune cell exhaustion, whi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czink, Elena, Kloor, Matthias, Goeppert, Benjamin, Fröhling, Stefan, Uhrig, Sebastian, Weber, Tim F., Meinel, Jörn, Sutter, Christian, Weiss, Karl Heinz, Schirmacher, Peter, Doeberitz, Magnus von Knebel, Jäger, Dirk, Springfeld, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593153/ https://www.ncbi.nlm.nih.gov/pubmed/28619747 http://dx.doi.org/10.1101/mcs.a001974

Ejemplares similares

The immune biology of microsatellite unstable cancer
por: von Knebel-Doeberitz, Magnus
Publicado: (2010)

Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma
por: Goeppert, Benjamin, et al.
Publicado: (2018)

Low frequency of mismatch repair deficiency in gallbladder cancer
por: Goeppert, Benjamin, et al.
Publicado: (2019)

Beta-2-microglobulin Mutations Are Linked to a Distinct Metastatic Pattern and a Favorable Outcome in Microsatellite-Unstable Stage IV Gastrointestinal Cancers
por: Busch, Elena, et al.
Publicado: (2021)

(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A
por: Michalak, Malwina, et al.
Publicado: (2020)

High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability
por: Michel, S, et al.
Publicado: (2008)

Complex pattern of immune evasion in MSI colorectal cancer
por: Ozcan, Mine, et al.
Publicado: (2018)

Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review
por: Bohaumilitzky, Lena, et al.
Publicado: (2020)

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
por: Ballhausen, Alexej, et al.
Publicado: (2020)

Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
por: Buckowitz, A, et al.
Publicado: (2005)

High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer
por: Pfuderer, Pauline L., et al.
Publicado: (2019)

Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
por: Tikidzhieva, A, et al.
Publicado: (2012)

Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
por: Charbel, Alphonse, et al.
Publicado: (2022)

Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability
por: Korff, Sebastian, et al.
Publicado: (2008)

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology
por: Woerner, Stefan M., et al.
Publicado: (2010)

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure
por: Haupt, Saskia, et al.
Publicado: (2021)

An undifferentiated carcinoma at Klatskin-position with long-term complete remission after chemotherapy
por: Köhler, Bruno Christian, et al.
Publicado: (2018)

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
por: Miao, Diana, et al.
Publicado: (2018)

New Molecular Tools for Efficient Screening of Cervical Cancer
por: Doeberitz, Magnus von Knebel
Publicado: (2001)

Plasma-based microsatellite instability detection strategy to guide immune checkpoint blockade treatment
por: Wang, Zhenghang, et al.
Publicado: (2020)

Combination Immunotherapies to Overcome Intrinsic Resistance to Checkpoint Blockade in Microsatellite Stable Colorectal Cancer
por: Kim, Chang Woo, et al.
Publicado: (2021)

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies
por: Sei, Shizuko, et al.
Publicado: (2023)

Differential Methylation of the HPV 16 Upstream Regulatory Region during Epithelial Differentiation and Neoplastic Transformation
por: Vinokurova, Svetlana, et al.
Publicado: (2011)

Biomarkers in Cervical Cancer Screening
por: Wentzensen, Nicolas, et al.
Publicado: (2007)

Foreword
por: von Knebel Doeberitz, Magnus, et al.
Publicado: (2007)

Low-dose immunogenic chemotherapeutics promotes immune checkpoint blockade in microsatellite stability colon cancer
por: Fang, Yuhang, et al.
Publicado: (2022)

Immune checkpoint blockade in ovarian cancer
por: Weiss, Lukas, et al.
Publicado: (2016)

Molecular genetics of microsatellite-unstable colorectal cancer for pathologists
por: Chen, Wei, et al.
Publicado: (2017)

N-Glycomic Profiling of Microsatellite Unstable Colorectal Cancer
por: Ukkola, Iiris, et al.
Publicado: (2023)

Role of DNA methylation in HPV associated lesions
por: von Knebel Doeberitz, Magnus, et al.
Publicado: (2019)

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma
por: Budczies, Jan, et al.
Publicado: (2021)

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
por: Chia, June A, et al.
Publicado: (2006)

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
por: Eggink, Florine A., et al.
Publicado: (2016)

Liver cancers with stem/progenitor-cell features – a rare chemotherapy-sensitive malignancy
por: Köhler, Bruno Christian, et al.
Publicado: (2017)

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters
por: Staffa, Laura, et al.
Publicado: (2015)

High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients
por: Reuschenbach, M, et al.
Publicado: (2011)

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
por: Chan, Edmond M., et al.
Publicado: (2019)

Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
por: Meltzer, Sebastian, et al.
Publicado: (2022)

Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer
por: Goeppert, B, et al.
Publicado: (2013)

Modeling the instantaneous normal mode spectra of liquids as that of unstable elastic media
por: Schirmacher, Walter, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_oqdn5fp6806m7vs8am4b7cd3he