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Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK

In protein kinase research, identifying and addressing small molecule binding sites other than the highly conserved ATP-pocket are of intense interest because this line of investigation extends our understanding of kinase function beyond the catalytic phosphotransfer. Such alternative binding sites...

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Detalles Bibliográficos
Autores principales:	Bührmann, Mike, Wiedemann, Bianca M., Müller, Matthias P., Hardick, Julia, Ecke, Maria, Rauh, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593189/ https://www.ncbi.nlm.nih.gov/pubmed/28892510 http://dx.doi.org/10.1371/journal.pone.0184627

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