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Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes

A large body of evidence indicates that particulate matter (PM)2.5 is associated with various negative effects on human health. However, the impact and molecular mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present study aimed to investigate the effects of two types of PM2...

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Autores principales: Liu, Qin, Wu, Jianbo, Song, Jiquan, Liang, Pin, Zheng, Kaiping, Xiao, Guifeng, Liu, Lanting, Zouboulis, Christos C., Lei, Tiechi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593471/
https://www.ncbi.nlm.nih.gov/pubmed/28849137
http://dx.doi.org/10.3892/ijmm.2017.3109
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author Liu, Qin
Wu, Jianbo
Song, Jiquan
Liang, Pin
Zheng, Kaiping
Xiao, Guifeng
Liu, Lanting
Zouboulis, Christos C.
Lei, Tiechi
author_facet Liu, Qin
Wu, Jianbo
Song, Jiquan
Liang, Pin
Zheng, Kaiping
Xiao, Guifeng
Liu, Lanting
Zouboulis, Christos C.
Lei, Tiechi
author_sort Liu, Qin
collection PubMed
description A large body of evidence indicates that particulate matter (PM)2.5 is associated with various negative effects on human health. However, the impact and molecular mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present study aimed to investigate the effects of two types of PM2.5 [water-soluble extracts (W-PM2.5) and non-water-soluble extracts (NW-PM2.5)] on cell proliferation, cell cycle progression, lipid synthesis, and inflammatory cytokine production of human SZ95 sebocytes. The results demonstrated that NW-PM2.5 and W-PM2.5 exposure dose-dependently inhibited SZ95 sebocyte proliferation by inducing G(1) cell arrest. Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1α (IL-1α), IL-6 and IL-8 in SZ95 sebocytes. Additionally, the expression of aryl hydrocarbon (Ah) receptor (AhR), AhR nuclear translocator protein (ARNT), as well as cytochrome P450 1A1 were significantly increased following PM2.5 exposure. Thus, these findings indicate that PM2.5 exerts inhibitory effects on cell proliferation and lipid synthesis, and stimulatory effects on inflammatory cytokine production and AhR signaling activation in human SZ95 sebocytes.
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spelling pubmed-55934712017-09-22 Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes Liu, Qin Wu, Jianbo Song, Jiquan Liang, Pin Zheng, Kaiping Xiao, Guifeng Liu, Lanting Zouboulis, Christos C. Lei, Tiechi Int J Mol Med Articles A large body of evidence indicates that particulate matter (PM)2.5 is associated with various negative effects on human health. However, the impact and molecular mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present study aimed to investigate the effects of two types of PM2.5 [water-soluble extracts (W-PM2.5) and non-water-soluble extracts (NW-PM2.5)] on cell proliferation, cell cycle progression, lipid synthesis, and inflammatory cytokine production of human SZ95 sebocytes. The results demonstrated that NW-PM2.5 and W-PM2.5 exposure dose-dependently inhibited SZ95 sebocyte proliferation by inducing G(1) cell arrest. Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1α (IL-1α), IL-6 and IL-8 in SZ95 sebocytes. Additionally, the expression of aryl hydrocarbon (Ah) receptor (AhR), AhR nuclear translocator protein (ARNT), as well as cytochrome P450 1A1 were significantly increased following PM2.5 exposure. Thus, these findings indicate that PM2.5 exerts inhibitory effects on cell proliferation and lipid synthesis, and stimulatory effects on inflammatory cytokine production and AhR signaling activation in human SZ95 sebocytes. D.A. Spandidos 2017-10 2017-08-25 /pmc/articles/PMC5593471/ /pubmed/28849137 http://dx.doi.org/10.3892/ijmm.2017.3109 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Qin
Wu, Jianbo
Song, Jiquan
Liang, Pin
Zheng, Kaiping
Xiao, Guifeng
Liu, Lanting
Zouboulis, Christos C.
Lei, Tiechi
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title_full Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title_fullStr Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title_full_unstemmed Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title_short Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
title_sort particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human sz95 sebocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593471/
https://www.ncbi.nlm.nih.gov/pubmed/28849137
http://dx.doi.org/10.3892/ijmm.2017.3109
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